191408-07-8Relevant articles and documents
Macrocyclic hydroxamate inhibitors of matrix metalloproteinases and TNF- α production
Cherney, Robert J.,Wang, Li,Meyer, Dayton T.,Chu-Biao, Xue,Arner, Elizabeth C.,Copeland, Robert A.,Covington, Maryanne B.,Hardman, Karl D.,Wasserman, Zelda R.,Jaffee, Bruce D.,Decicco, Carl P.
, p. 1279 - 1284 (1999)
Several macrocyclic, hydroxamate derivatives were synthesized and evaluated as inhibitors of matrix metalloproteinases (MMPs) and turnout necrosis factor-α (TNF-α) production. These macrocycles are anti-succinate based inhibitors linked from P1 to P2'. A