Macrocyclic hydroxamate inhibitors of matrix metalloproteinases and TNF- α production

DOI: 10.1016/S0960-894X(99)00178-X

Source and publish data:

Bioorganic and Medicinal Chemistry Letters p. 1279 - 1284 (1999)

Update date:2022-08-03

Topics:

Authors:

Cherney, Robert J.

Wang, Li

Meyer, Dayton T.

Chu-Biao, Xue

Arner, Elizabeth C.

Copeland, Robert A.

Covington, Maryanne B.

Hardman, Karl D.

Wasserman, Zelda R.

Jaffee, Bruce D.

Decicco, Carl P.

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Article abstract of DOI:10.1016/S0960-894X(99)00178-X

Several macrocyclic, hydroxamate derivatives were synthesized and evaluated as inhibitors of matrix metalloproteinases (MMPs) and turnout necrosis factor-α (TNF-α) production. These macrocycles are anti-succinate based inhibitors linked from P1 to P2'. A

Full text of DOI:10.1016/S0960-894X(99)00178-X

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