Macrocyclic hydroxamate inhibitors of matrix metalloproteinases and TNF- α production

DOI: 10.1016/S0960-894X(99)00178-X

Source and publish data:

Bioorganic and Medicinal Chemistry Letters p. 1279 - 1284 (1999)

Update date:2022-08-03

Topics:

Authors:

Cherney, Robert J.

Wang, Li

Meyer, Dayton T.

Chu-Biao, Xue

Arner, Elizabeth C.

Copeland, Robert A.

Covington, Maryanne B.

Hardman, Karl D.

Wasserman, Zelda R.

Jaffee, Bruce D.

Decicco, Carl P.

Read Full Text PDF DownLoad Join now for total 90,000,000 free articles

Article abstract of DOI:10.1016/S0960-894X(99)00178-X

Several macrocyclic, hydroxamate derivatives were synthesized and evaluated as inhibitors of matrix metalloproteinases (MMPs) and turnout necrosis factor-α (TNF-α) production. These macrocycles are anti-succinate based inhibitors linked from P1 to P2'. A

Full text of DOI:10.1016/S0960-894X(99)00178-X

Products guided by the article

Product name:(2S,3R)-2-(3-Hydroxy-propyl)-5-methyl-3-[(S)-1-methylcarbamoyl-5-(4-nitro-benzenesulfonylamino)-pentylcarbamoyl]-hexanoic acid tert-butyl ester

Cas No:191408-07-8

R&D Labs maybe for 191408-07-8

Hunan Dinuo Pharmaceutical Co.,Ltd.

Contact:86-731-88280100*8561

Address:Bio-pharmaceutical industrial park, Liuyang, Hunan, China
Shandong Shouguang Songchuan Industrial Additives Co.,Ltd

Contact:+86-536-8566856

Address:Shouguang,Shandong,China
Hangzhou Pharma & Chem Co.,Ltd.

Contact:+86-571-87040515

Address:No,139Qingchun Rd
Nanjing Norris Pharm Technology Co., Ltd.

Contact:+86-13901585132

Address:2 Qiande Road, Jiangning sciencepark Hi-Tech Zone, Nanjing, P.R.China
Changsha Yihai Chemical Technology Co.,ltd

website:http://www.cs-yihai.com/

Contact:0731- 85620465

Address:Room 23005, unit 2, the northern building of Xiangsong international building , NO.259 Shaoshan Road , Changsha , Hunan, China.(mainland)

Relevant to this article

Doi:10.1039/JR9540001119
()
Reactions of α,β-enones with diazo compounds, 2: Synthesis of dihydrofuran derivatives

Doi:10.1002/jlac.199719970630
(1997)
Synthesis of ferrocenyl-1,2-diketones and related compounds: Crystal and molecular structures of 1,2-diferrocenylethanedione and 1-ferrocenyl-2-(4-biphenylyl) ethanedione

Doi:10.1016/S0022-328X(96)06642-9
(1997)
Tandem radical mediated 5-exo-trig, 6-endo-dig cyclization. Stereoselectivity, α-trimethylsilyl effect and the product spread - IV

Doi:10.1016/S0040-4020(97)00519-X
(1997)
Preparation of imido pentamethylcyclopentadienyl molybdenum(IV) complexes: X-ray molecular structure of cis-[MoCp * Cl(μ-N^tBu)]₂C₆H₆

Doi:10.1016/S0022-328X(96)06855-6
(1997)
Functionalised acyl ferrocenes: Crystal and molecular structures of 4-aminobenzoylferrocene, 4-hydroxybenzoylferrocene and 1,1′-bis(4-hydroxybenzoyl)ferrocene

Doi:10.1016/S0022-328X(97)00079-X
(1997)

Article Doi