Macrocyclic hydroxamate inhibitors of matrix metalloproteinases and TNF- α production

DOI: 10.1016/S0960-894X(99)00178-X

Source and publish data:

Bioorganic and Medicinal Chemistry Letters p. 1279 - 1284 (1999)

Update date:2022-08-03

Topics:

Authors:

Cherney, Robert J.

Wang, Li

Meyer, Dayton T.

Chu-Biao, Xue

Arner, Elizabeth C.

Copeland, Robert A.

Covington, Maryanne B.

Hardman, Karl D.

Wasserman, Zelda R.

Jaffee, Bruce D.

Decicco, Carl P.

Read Full Text PDF DownLoad Join now for total 90,000,000 free articles

Article abstract of DOI:10.1016/S0960-894X(99)00178-X

Several macrocyclic, hydroxamate derivatives were synthesized and evaluated as inhibitors of matrix metalloproteinases (MMPs) and turnout necrosis factor-α (TNF-α) production. These macrocycles are anti-succinate based inhibitors linked from P1 to P2'. A

Full text of DOI:10.1016/S0960-894X(99)00178-X

Products guided by the article

Product name:(2S,3R)-2-(3-Hydroxy-propyl)-5-methyl-3-[(S)-1-methylcarbamoyl-5-(4-nitro-benzenesulfonylamino)-pentylcarbamoyl]-hexanoic acid tert-butyl ester

Cas No:191408-07-8

R&D Labs maybe for 191408-07-8

Shanghai HengXun Pharmaceutical Tech. Co., Ltd.

Contact:86-86-52730756

Address:Room 603, No. 240, Tianmuzhong Road, Zhabei, Shanghai, China
ShenZhen InnoSyn Biotech Co.,Ltd

website:http://www.innosyns.com

Contact:+86-755-28351685

Address:Floor 5 & 6, Building A1, HAIKEXING Strategic Innovative Industrial Park, 16 BaoShan Road, PingShan District
Wuhan Chemchemical Co., Ltd.(expird)

Contact:15973022782

Address:7-5-6218,Incubation Centre,Guandong Industry Park, East Lake High-Tech Development Zone,Wuhan City.
Jiangxi Huashi Pharmaceutical Co., Ltd

Contact:+86-795-4509628

Address:Ningbo Ave., Fengtian Industrial Park, Fengxin Country, Jiangxi, China.
Fuxin Jintelai Fluorin Chemical Co., Ltd.

Contact:+86-0418-8229599

Address:, 7th Huagong Road, Fluorine industry development zone (Yimatu Town,Fumeng County),Fuxin City, Liaoning Province, China

Relevant to this article

Doi:10.1039/JR9540001119
()
Reactions of α,β-enones with diazo compounds, 2: Synthesis of dihydrofuran derivatives

Doi:10.1002/jlac.199719970630
(1997)
Synthesis of ferrocenyl-1,2-diketones and related compounds: Crystal and molecular structures of 1,2-diferrocenylethanedione and 1-ferrocenyl-2-(4-biphenylyl) ethanedione

Doi:10.1016/S0022-328X(96)06642-9
(1997)
Tandem radical mediated 5-exo-trig, 6-endo-dig cyclization. Stereoselectivity, α-trimethylsilyl effect and the product spread - IV

Doi:10.1016/S0040-4020(97)00519-X
(1997)
Preparation of imido pentamethylcyclopentadienyl molybdenum(IV) complexes: X-ray molecular structure of cis-[MoCp * Cl(μ-N^tBu)]₂C₆H₆

Doi:10.1016/S0022-328X(96)06855-6
(1997)
Functionalised acyl ferrocenes: Crystal and molecular structures of 4-aminobenzoylferrocene, 4-hydroxybenzoylferrocene and 1,1′-bis(4-hydroxybenzoyl)ferrocene

Doi:10.1016/S0022-328X(97)00079-X
(1997)

Article Doi