191408-26-1

Upstream product

• 82859-39-0 trans-cinnamyl iodide 
• 191408-24-9 2R,3S-Methyl 4-benzyloxy-3-hydroxy-2-(2E-3-phenyl-2-propen-1-yl)butyrate 
• 147849-60-3 Methyl (S)-4-(benzyloxy)-3-hydroxybutanoate 
• 4392-24-9 Cinnamyl bromide 
• 14618-80-5 (R)-benzyl glycidol 
• 178932-85-9 N-δ-tert-butoxycarbonyl-L-ornithine methyl amide 
• 191408-25-0 2R,3S-4-Benzyloxy-3-hydroxy-2-(2E-3-phenyl-2-propen-1-yl)butyric acid 

Downstream Products

• 191408-27-2 ((S)-4-{(E)-(R)-2-[(S)-2-Benzyloxy-1-((E)-4-bromo-but-2-enyloxy)-ethyl]-5-phenyl-pent-4-enoylamino}-4-methylcarbamoyl-butyl)-carbamic acid tert-butyl ester 
• 191408-40-9 ((S)-4-{(E)-(R)-2-[(S)-2-Benzyloxy-1-(2-bromomethyl-allyloxy)-ethyl]-5-phenyl-pent-4-enoylamino}-4-methylcarbamoyl-butyl)-carbamic acid tert-butyl ester 
• 191408-31-8 (2S,3R,6S)-2-Benzyloxycarbamoyl-6-methylcarbamoyl-4-oxo-3-(3-phenyl-propyl)-1-oxa-5,10-diaza-cyclotetradecane-10-carboxylic acid tert-butyl ester 
• 191408-34-1 (2S,3R,6S)-10-Acetyl-4-oxo-3-(3-phenyl-propyl)-1-oxa-5,10-diaza-cyclotetradecane-2,6-dicarboxylic acid 2-(benzyloxy-amide) 6-methylamide 
• 191408-45-4 (2S,3R,6S)-10-Acetyl-12-methyl-4-oxo-3-(3-phenyl-propyl)-1-oxa-5,10-diaza-cyclotridecane-2,6-dicarboxylic acid 2-(benzyloxy-amide) 6-methylamide 
• 191408-42-1 (2S,3R,6S)-10-Acetyl-2-benzyloxymethyl-12-methylene-4-oxo-3-((E)-3-phenyl-allyl)-1-oxa-5,10-diaza-cyclotridecane-6-carboxylic acid methylamide 
• 791043-26-0 (2S,3R,6S)-4-Oxo-3-(3-phenyl-propyl)-1-oxa-5,10-diaza-cyclotetradecane-2,6-dicarboxylic acid 2-(benzyloxy-amide) 6-methylamide 
• 191408-30-7 (2S,3R,6S)-6-Methylcarbamoyl-4-oxo-3-(3-phenyl-propyl)-1-oxa-5,10-diaza-cyclotetradecane-2,10-dicarboxylic acid 10-tert-butyl ester 
• 191408-29-4 (2S,3R,6S)-2-Hydroxymethyl-6-methylcarbamoyl-4-oxo-3-(3-phenyl-propyl)-1-oxa-5,10-diaza-cyclotetradecane-10-carboxylic acid tert-butyl ester 
• 191408-44-3 (2S,3R,6S)-10-Acetyl-12-methyl-6-methylcarbamoyl-4-oxo-3-(3-phenyl-propyl)-1-oxa-5,10-diaza-cyclotridecane-2-carboxylic acid 
• 191408-43-2 (2S,3R,6S)-10-Acetyl-2-hydroxymethyl-12-methyl-4-oxo-3-(3-phenyl-propyl)-1-oxa-5,10-diaza-cyclotridecane-6-carboxylic acid methylamide 

Relevant academic research and scientific papers

P1, P2'-linked macrocyclic amine derivatives as matrix metalloproteinase inhibitors

A novel series of 13- and 14-membered macrocyclic amines was developed by linking the P1 and P2' groups. The synthesis entails stereoselective Frater alkylation to install the anti-succinate configuration and macrocyclic amination via nucleophilic displacement. This strategy resulted in a new class of conformationally constrained inhibitors that are potent and selective for MMP-8 and 9 over MMP-1 and 3.