191408-44-3

Upstream product

• 82859-39-0 trans-cinnamyl iodide 
• 178932-85-9 N-δ-tert-butoxycarbonyl-L-ornithine methyl amide 
• 4392-24-9 Cinnamyl bromide 
• 191408-25-0 2R,3S-4-Benzyloxy-3-hydroxy-2-(2E-3-phenyl-2-propen-1-yl)butyric acid 
• 191408-24-9 2R,3S-Methyl 4-benzyloxy-3-hydroxy-2-(2E-3-phenyl-2-propen-1-yl)butyrate 
• 191408-26-1 {(S)-4-[(E)-(R)-2-((S)-2-Benzyloxy-1-hydroxy-ethyl)-5-phenyl-pent-4-enoylamino]-4-methylcarbamoyl-butyl}-carbamic acid tert-butyl ester 
• 191408-40-9 ((S)-4-{(E)-(R)-2-[(S)-2-Benzyloxy-1-(2-bromomethyl-allyloxy)-ethyl]-5-phenyl-pent-4-enoylamino}-4-methylcarbamoyl-butyl)-carbamic acid tert-butyl ester 
• 191408-42-1 (2S,3R,6S)-10-Acetyl-2-benzyloxymethyl-12-methylene-4-oxo-3-((E)-3-phenyl-allyl)-1-oxa-5,10-diaza-cyclotridecane-6-carboxylic acid methylamide 
• 191408-43-2 (2S,3R,6S)-10-Acetyl-2-hydroxymethyl-12-methyl-4-oxo-3-(3-phenyl-propyl)-1-oxa-5,10-diaza-cyclotridecane-6-carboxylic acid methylamide 

Relevant academic research and scientific papers

P1, P2'-linked macrocyclic amine derivatives as matrix metalloproteinase inhibitors

A novel series of 13- and 14-membered macrocyclic amines was developed by linking the P1 and P2' groups. The synthesis entails stereoselective Frater alkylation to install the anti-succinate configuration and macrocyclic amination via nucleophilic displacement. This strategy resulted in a new class of conformationally constrained inhibitors that are potent and selective for MMP-8 and 9 over MMP-1 and 3.