19141-74-3

Usage

Uses

Used in Plastics Industry:
(3-chloropropyl)oxirane is used as a reactive diluent for [enhancing the processability and reducing the viscosity of epoxy resins], which is essential in the manufacturing of various plastic products.
Used in Adhesives Industry:
(3-chloropropyl)oxirane is used as a crosslinking agent for [improving the mechanical properties and thermal stability of adhesives], ensuring strong bonding and durability in a wide range of applications.
Used in Coatings Industry:
(3-chloropropyl)oxirane is used as a component in coating formulations for [providing enhanced adhesion, chemical resistance, and durability to the coatings], making them suitable for various surfaces and environments.

InChI:InChI=1/C5H9ClO/c6-3-1-2-5-4-7-5/h5H,1-4H2

Upstream product

• 928-50-7 5-chloropent-1-ene 
• 821-09-0 n-Pent-4-enyl alcohol 
• 89280-57-9 1,5?dichloro?2?pentanol 

Downstream Products

• 85275-45-2 N-tert-butoxycarbonyl-3-piperidinol 
• 6859-99-0 3-hydroxypiperazine 
• 94157-97-8 1?amino?5?chloro?2?pentanol 
• 20074-80-0 5-chloro-pentanal 
• 63791-08-2 1,1,1-triphenyl-hexahydro-cyclopenta[c][1,2]oxaphosphole 
• 63791-00-4 7,7,7-triphenyl-6-oxa-7λ⁵-phospha-bicyclo[3.2.1]octane 

Relevant academic research and scientific papers

Preparation method of (S)-N-BOC-3-hydroxypiperidine

The invention provides a preparation method of (S)-N-BOC-3-hydroxypiperidine. The preparation method comprises the following steps: carrying out a reaction on (S)-epichlorohydrin with a 2-chloroethylmagnesium bromide Grignard reagent to obtain (S)-1,5-dichloro-2-pentanol, carrying out an intramolecular cyclization reaction in the presence of an alkaline substance to generate (S)-5-chloro-1,2-epoxypentane, carrying out a reaction on the (S)-5-chloro-1,2-epoxypentane with an ammonia solution to generate (S)-1-amino-5-chloro-2-pentanol, then carrying out an intramolecular cyclization reaction onthe (S)-1-amino-5-chloro-2-pentanol to obtain (S)-3-hydroxypiperidine, and finally carrying out a reaction with BOC anhydride to obtain the product (S)-N-BOC-3-hydroxypiperidine. The preparation method disclosed by the invention has the advantages of short synthesis route, few side reactions and high yield; the product has good quality and is convenient for purification. The raw materials are easily available and has low price; the reaction conditions are mild; and safety is high. The preparation method is environmentally friendly, is simple and practice, and is suitable for industrial batchproduction.

Rational synthesis of contra-thermodynamic spiroacetals by reductive cyclizations

A synthesis of spiroacetals was developed using a reductive cyclization strategy that leads stereoselectively to spiroacetals with a single anomeric stabilization. The method begins with the synthesis of spiro ortho esters. The ortho ester is converted to a cyano acetal. Reductive lithiation of the cyano acetal generates an axial dialkoxylithium reagent, and intramolecular cyclization produces a new ring with retention of configuration. The strategy is convergent and produces complex spiro acetals in only a few steps. The method will be useful in the synthesis of natural products and will facilitate the synthesis of previously inaccessible contra-thermodynamic acetals. Copyright