94157-97-8

Basic information

• Product Name: 1-amino-5-chloropentan-2-ol
• Synonyms: 1-amino-5-chloropentan-2-ol;1-Amino-5-chloro-2-pentanol
• CAS NO: 94157-97-8
• Molecular Formula: C5H12ClNO
• Molecular Weight: 137.60788
• EINECS: 303-066-1
• Mol File: 94157-97-8.mol
• Article Data: 1

Chemical Properties

• Boiling Point: 262.3°Cat760mmHg
• Flash Point: 112.4°C
• Appearance: /
• Density: 1.109g/cm³
• Vapor Pressure: 0.00156mmHg at 25°C
• Refractive Index: 1.477
• CAS DataBase Reference: 1-amino-5-chloropentan-2-ol(CAS DataBase Reference)
• NIST Chemistry Reference: 1-amino-5-chloropentan-2-ol(94157-97-8)
• EPA Substance Registry System: 1-amino-5-chloropentan-2-ol(94157-97-8)

Safety Data

• Hazardous Substances Data: 94157-97-8(Hazardous Substances Data)

Usage

Derivative

Pentanol

Chlorine atom

Attached to the fifth carbon

Amino group

Attached to the first carbon

Physical state

Colorless liquid

Odor

Slightly sweet

Primary use

Intermediate in the synthesis of pharmaceuticals and other organic compounds

Presence of amino and hydroxyl groups

Useful in the production of various pharmacological agents

Reagent

Used in organic chemistry reactions

Classification

Hazardous substance

Handling

Requires proper care and precautions

InChI:InChI=1/C5H12ClNO/c6-3-1-2-5(8)4-7/h5,8H,1-4,7H2

Upstream product

• 89280-57-9 1,5?dichloro?2?pentanol 
• 19141-74-3 5?chloro?1,2?epoxypentane 

Relevant articles and documents

Preparation method of (S)-N-BOC-3-hydroxypiperidine

The invention provides a preparation method of (S)-N-BOC-3-hydroxypiperidine. The preparation method comprises the following steps: carrying out a reaction on (S)-epichlorohydrin with a 2-chloroethylmagnesium bromide Grignard reagent to obtain (S)-1,5-dichloro-2-pentanol, carrying out an intramolecular cyclization reaction in the presence of an alkaline substance to generate (S)-5-chloro-1,2-epoxypentane, carrying out a reaction on the (S)-5-chloro-1,2-epoxypentane with an ammonia solution to generate (S)-1-amino-5-chloro-2-pentanol, then carrying out an intramolecular cyclization reaction onthe (S)-1-amino-5-chloro-2-pentanol to obtain (S)-3-hydroxypiperidine, and finally carrying out a reaction with BOC anhydride to obtain the product (S)-N-BOC-3-hydroxypiperidine. The preparation method disclosed by the invention has the advantages of short synthesis route, few side reactions and high yield; the product has good quality and is convenient for purification. The raw materials are easily available and has low price; the reaction conditions are mild; and safety is high. The preparation method is environmentally friendly, is simple and practice, and is suitable for industrial batchproduction.