191419-07-5

Basic information

• Product Name: Pyridine, 2,3-dichloro-4-methyl- (9CI)
• Synonyms: 2,3-DICHLORO-4-PICOLINE;2,3-Dichloro-4-methylpyridine;Pyridine, 2,3-dichloro-4-methyl- (9CI)
• CAS NO: 191419-07-5
• Molecular Formula: C6H5Cl2N
• Molecular Weight: 162.0166
• EINECS: 1312995-182-4
• Product Categories: HALIDE;Pyridine
• Mol File: 191419-07-5.mol
• Article Data: 2

Chemical Properties

• Boiling Point: 224.789 °C at 760 mmHg
• Flash Point: 111.23 °C
• Appearance: /
• Density: 1.319
• Vapor Pressure: 0.134mmHg at 25°C
• Refractive Index: 1.547
• Storage Temp.: under inert gas (nitrogen or Argon) at 2-8°C
• PKA: 0.17±0.10(Predicted)
• CAS DataBase Reference: Pyridine, 2,3-dichloro-4-methyl- (9CI)(CAS DataBase Reference)
• NIST Chemistry Reference: Pyridine, 2,3-dichloro-4-methyl- (9CI)(191419-07-5)
• EPA Substance Registry System: Pyridine, 2,3-dichloro-4-methyl- (9CI)(191419-07-5)

Safety Data

• Hazardous Substances Data: 191419-07-5(Hazardous Substances Data)

Usage

General Description

Pyridine, 2,3-dichloro-4-methyl- (9CI) is a chemical compound that belongs to the pyridine class of compounds. It is characterized by the presence of two chlorine atoms and a methyl group on the pyridine ring. Pyridine, 2,3-dichloro-4-methyl- (9CI) is commonly used as a building block in organic synthesis and pharmaceutical research due to its versatile reactivity and ability to participate in various chemical reactions. It is also employed as a reagent in the production of pharmaceuticals, agrochemicals, and other fine chemicals. Additionally, it is used in the manufacturing of dyes, pigments, rubber chemicals, and other industrial products. However, it is important to handle this chemical with caution as it may pose health and environmental hazards.

InChI:InChI=1/C6H5Cl2N/c1-4-2-3-9-6(8)5(4)7/h2-3H,1H3

Upstream product

• 2402-77-9 2,3-dichloro-pyridine 
• 74-88-4 methyl iodide 

Relevant articles and documents

Extending motifs in lithiocuprate chemistry: Unexpected structural diversity in thiocyanate complexes

The new area of lithio(thiocyanato)cuprates has been developed. Using inexpensive, stable and safe CuSCN for their preparation, these complexes revealed Lipshutz-type dimeric motifs with solvent-dependent point group identities; planar, boat-shaped and chair shaped conformers are seen in the solid state. In solution, both Lipshutz-type and Gilman structures are clearly seen. Since the advent in 2007 of directed ortho cupration, effort has gone into understanding the structure-reactivity effects of amide ligand variation in and alkali metal salt abstraction from Lipshutz-type cuprates such as (TMP)2Cu(CN)Li2(THF) 1 (TMP = 2,2,6,6-tetramethylpiperidide). The replacement of CN- with SCN- is investigated presently as a means of improving the safety of lithium cuprates. The synthesis and solid state structural characterization of reference cuprate (TMP)2Cu(CN)Li2(THP) 8 (THP = tetrahydropyran) precedes that of the thiocyanate series (TMP)2Cu(SCN)Li2(L) (L = OEt29, THF 10, THP 11). For each of 9-11, preformed TMPLi was combined with CuSCN (2 : 1) in the presence of sub-stoichiometric Lewis base (0.5 eq. wrt Li). The avoidance of Lewis basic solvents incurs formation of the unsolvated Gilman cuprate (TMP)2CuLi 12, whilst multidimensional NMR spectroscopy has evidenced the abstraction of LiSCN from 9-11 in hydrocarbon solution and the in situ formation of Gilman reagents. The synthetic utility of 10 is established in the selective deprotometalation of chloropyridine substrates, including effecting transition metal-free homocoupling in 51-69% yield.