191427-11-9Relevant academic research and scientific papers
Enantioselective homogeneous catalysis and the '3,5-dialkyl meta- effect'. MeO-BIPHEP complexes related to heck, allylic alkylation, and hydrogenation chemistry
Trabesinger, Gerald,Albinati, Alberto,Feiken, Nantko,Kunz, Roland W.,Pregosin, Paul S.,Tschoerner, Matthias
, p. 6315 - 6323 (2007/10/03)
The enantioselectivities arising from a Pd-catalyzed Heck reaction (>98% ee) and an allylic alkylation (>90% ee) using a 3,5-di-tert-butyl-MeO-BIPHEP chiral auxiliary (1) are reported. Higher ee's are observed with the 3,5- dialkyl substituents than with
