1915-02-2Relevant academic research and scientific papers
Catalyst and solvent free, microwave assisted synthesis of 3-isoindolo-2-yl-2-substituted quinazolin-4(3H)-ones
Khan, Rasool,Arfan, Mohammad,Mohammadzai, Imdadullah,Naeem, Mohammad
, p. 1505 - 1507 (2014/03/21)
In the present work, we document a new microwave asisted and direct thermal fussion method for preperation of 3-isoindolo-2-substituted-quinazolin-4(3H)- ones under solvent and catalyst free conditions. Both methods are much convineant, green and faster and high yielding. Microwave method was proved to be high yielding and faster as compared to the direct thermal fusion method.
Studies on quinazolines: Part II-Synthesis and antimicrobial evaluation of some 2,2-disubstituted-3,3-biquinazolin-4(3H)-ones
Wasfy
, p. 3102 - 3107 (2007/10/03)
N-(2-Styryl-, 2-p-chlorostyryl- or 2-p-nitrostyryl-4-oxo-3H-quinazolin-3-yl)-2-aminobenzamides 6a-c react with triethyl orthoesters to furnish some new 2-styryl-, 2-p-chlorostyryl- or 2-p-nitrostyryl-2-substituted-3,3-biqui-nazolin-4(3H)-ones (7a-c-9a-c). An alternative synthesis of (7-9)b has been accomplished by reaction of acetylanthranil with 2-amino-2-styryl-, 2-p-chlorostyryl- or 2-p-nitrostyryl-quinazolin-4(3H)-ones 4a-c. The synthesised products are tested for antimicrobial activities using methaqualone as reference standard.
