201292-87-7Relevant academic research and scientific papers
Studies on quinazolines: Part II-Synthesis and antimicrobial evaluation of some 2,2-disubstituted-3,3-biquinazolin-4(3H)-ones
Wasfy
, p. 3102 - 3107 (2007/10/03)
N-(2-Styryl-, 2-p-chlorostyryl- or 2-p-nitrostyryl-4-oxo-3H-quinazolin-3-yl)-2-aminobenzamides 6a-c react with triethyl orthoesters to furnish some new 2-styryl-, 2-p-chlorostyryl- or 2-p-nitrostyryl-2-substituted-3,3-biqui-nazolin-4(3H)-ones (7a-c-9a-c). An alternative synthesis of (7-9)b has been accomplished by reaction of acetylanthranil with 2-amino-2-styryl-, 2-p-chlorostyryl- or 2-p-nitrostyryl-quinazolin-4(3H)-ones 4a-c. The synthesised products are tested for antimicrobial activities using methaqualone as reference standard.
