1915-80-6

Basic information

• Product Name: 2-Methyl-3-(2,4-dimethylphenyl)quinazolin-4(3H)-one
• Synonyms: 2-Methyl-3-(2,4-dimethylphenyl)quinazolin-4(3H)-one;3-(2,4-Dimethylphenyl)-2-methylquinazolin-4(3H)-one
• CAS NO: 1915-80-6
• Molecular Formula: C₁₇H₁₆N₂O
• Molecular Weight: 0
• Mol File: 1915-80-6.mol
• Article Data: 5

Chemical Properties

• Boiling Point: 433.8°C at 760 mmHg
• Flash Point: 216.2°C
• Appearance: /
• Density: 1.14g/cm³
• Vapor Pressure: 9.95E-08mmHg at 25°C
• Refractive Index: 1.614
• CAS DataBase Reference: 2-Methyl-3-(2,4-dimethylphenyl)quinazolin-4(3H)-one(CAS DataBase Reference)
• NIST Chemistry Reference: 2-Methyl-3-(2,4-dimethylphenyl)quinazolin-4(3H)-one(1915-80-6)
• EPA Substance Registry System: 2-Methyl-3-(2,4-dimethylphenyl)quinazolin-4(3H)-one(1915-80-6)

Safety Data

• Hazardous Substances Data: 1915-80-6(Hazardous Substances Data)

Usage

Uses

Methylmethaqualone is an analogue of methaqualone that has similar sedative and hypnotic properties to its parent compound (resulting from its agonist activity at the β subtype of the GABAA receptor), and is around the same potency.

InChI:InChI=1/C17H16N2O/c1-11-8-9-16(12(2)10-11)19-13(3)18-15-7-5-4-6-14(15)17(19)20/h4-10H,1-3H3

Upstream product

• 24122-43-8 3-(2,4-dimethylphenyl)-4-(3H)quinazolinone 
• 21132-02-5 2-amino-N-(2,4-dimethylphenyl)benzamide 

Relevant articles and documents

Metal-free C-H methylation and acetylation of heteroarenes with PEG-400

The generation of a methyl carbon source from renewable and cheap sources is challenging. Herein, we describe a novel and an efficient route for methylation and acetylation of aza-heteroarenes using PEG-400 under O2and TsOH·H2O for the first time by tuning the reaction conditions using a different set of starting materials. The key features of the current protocol are oxidative C-O and C-C bond scission under metal-free conditions with good functional group tolerance, and a broad substrate scope. The potential applicability of the designed methodology was demonstrated for the synthesis of central nervous system (CNS) depressant and anticonvulsant drug molecules by a one-pot strategy.

Role of alkyl substitution in 2,3-disubstituted and 3-substituted 4-quinazolones on the inhibition of pyruvic acid oxidation.

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Some 2, 3-disubstituted 3H-4-quinazolones and 3H-4-thioquinazolones.

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