19152-36-4

Basic information

• Product Name: 3,4-DIMETHOXY-2'-HYDROXYCHALCONE
• Synonyms: 3,4-DIMETHOXY-2'-HYDROXYCHALCONE;2'-HYDROXY-3,4-DIMETHOXYCHALCONE;3-(3,4-DIMETHOXYPHENYL)-1-(2-HYDROXYPHENYL)PROP-2-EN-1-ONE
• CAS NO: 19152-36-4
• Molecular Formula: C₁₇H₁₆O₄
• Molecular Weight: 284.31
• Product Categories: Chalcones
• Mol File: 19152-36-4.mol
• Article Data: 63

Chemical Properties

• Boiling Point: 466.4°Cat760mmHg
• Flash Point: 171.5°C
• Appearance: /
• Density: 1.203g/cm³
• Storage Temp.: Sealed in dry,Room Temperature
• Solubility: Chloroform (Slightly), Ethyl Acetate (Slightly)
• Stability: Light Sensitive
• CAS DataBase Reference: 3,4-DIMETHOXY-2'-HYDROXYCHALCONE(CAS DataBase Reference)
• NIST Chemistry Reference: 3,4-DIMETHOXY-2'-HYDROXYCHALCONE(19152-36-4)
• EPA Substance Registry System: 3,4-DIMETHOXY-2'-HYDROXYCHALCONE(19152-36-4)

Safety Data

• Hazardous Substances Data: 19152-36-4(Hazardous Substances Data)

Usage

Uses

2''-Hydroxy-3,4-dimethoxychalcone, is a building block used in various chemical synthesis such as in the synthesis of new flavanoid and chalcone derivatives as antimicrobial agent by green chemistry approach.

Upstream product

• 118-93-4 o-hydroxyacetophenone 
• 120-14-9 3,4-dimethoxy-benzaldehyde 
• 39856-08-1 3,4-dimethoxy-cinnamoyl chloride 
• 108-95-2 phenol 

Downstream Products

• 134720-25-5 2-(3,4-dimethoxyphenyl)-4-(2-hydroxyphenyl)-2,3-dihydro-1H-1,5-benzodiazepine 
• 81136-28-9 3-(2-hydroxyphenyl)-5-(3,4-dimethoxyphenyl)-4,5-dihydro-1H-pyrazole 
• 189073-42-5 RuCl₂(C₆H₄(O)C(O)CHCHC₆H₃(OCH₃)2)(P(C₆H₅)3)2 
• 1206209-96-2 C₁₈H₁₉N₃O₃S 
• 77815-35-1 C₁₇H₁₃ClO₄ 
• 250640-55-2 2-[2-(3,4-dimethoxyphenyl)-2,3-dihydrobenzo[b][1,4]thiazepin-4-yl]phenol 
• 120645-73-0 3-(2-hydroxyphenyl)-1-(3,4-dimethoxyphenyl)propan-1-one 
• 6344-21-4 3',4'-dimethoxyflavanone 
• 90846-64-3 4-[(E)-2-(3,4-Dimethoxy-phenyl)-vinyl]-chromen-2-one 
• 6889-80-1 2-(3,4-dimethoxyphenyl)-3-hydroxy-4H-chromen-4-one 
• 88701-90-0 4-[(E)-2-(3,4-Dimethoxy-phenyl)-vinyl]-benzo[e][1,2,3]oxathiazine 2,2-dioxide 
• 88701-95-5 C₁₈H₁₆ClNO₇S 
• 88701-90-0 4-[(E)-2-(3,4-Dimethoxy-phenyl)-vinyl]-benzo[e][1,2,3]oxathiazine 2,2-dioxide 
• 902149-22-8 C₂₃H₁₈N₄O₇ 

Relevant articles and documents

Crystal structures, Hirshfeld surface analysis and PIXEL calculations of four (E)-1-(2-hydroxyphenyl)-3-phenylprop-2-en-1-one derivatives, containing methoxy substituents. The importance of π interactions

A detailed structural analysis has been carried out on four chalcone (E)-1-(2-hydroxyphenyl)-3-phenylprop-2-en-1-one derivatives, having a varying number of methoxy substituents, namely (E)-3-(3,4-dimethoxyphenyl)-1-(2-hydroxyphenyl)prop-2-en-1-one, (1),

A new class of flavonol-based anti-prostate cancer agents: Design, synthesis, and evaluation in cell models

Flavonoids are a large class of polyphenolic compounds ubiquitously distributed in dietary plants with an array of biological activities. Flavonols are a major sub-class of flavonoids featuring a hydroxyl group at C-3. Certain natural flavonols, such as q

Convenient synthesis of flavanone derivatives via oxa-Michael addition using catalytic amount of aqueous cesium fluoride

A total of 36 flavanones, which included polycyclic aromatic and heterocyclic rings, were readily synthesized via oxa-Michael addition from the corresponding hydroxychalcones with a catalytic amount of aqueous cesium fluoride solution under mild conditions. This method could be applied to the scalable synthesis of eriodictyol as a known potent inhibitor of the SARS-CoV-2 spike protein.

A novel one-pot synthesis of flavones

In this paper, a one-pot facile route for the BiCl3/RuCl3-mediated synthesis of functionalized flavones is described, including: (i) intermolecularortho-acylation of substituted phenols with cinnamoyl chlorides, and (ii) intramolecular cyclodehydrogenation of the resultingo-hydroxychalcones. The reaction conditions are discussed herein.