19152-39-7

Basic information

• Product Name: 4'-HYDROXY-3,4-METHYLENEDIOXYCHALCONE
• Synonyms: TIMTEC-BB SBB002402;4'-HYDROXY-3,4-METHYLENEDIOXYCHALCONE;3-(1,3-BENZODIOXOL-5-YL)-1-(4-HYDROXYPHENYL)-2-PROPEN-1-ONE;2-Propen-1-one, 3-(1,3-benzodioxol-5-yl)-1-(4-hydroxyphenyl)-;3-(Benzo[d][1,3]dioxol-5-yl)-1-(4-hydroxyphenyl)prop-2-en-1-one
• CAS NO: 19152-39-7
• Molecular Formula: C₁₆H₁₂O₄
• Molecular Weight: 268.26
• Mol File: 19152-39-7.mol
• Article Data: 11

Chemical Properties

• Boiling Point: 482.6 °C at 760 mmHg
• Flash Point: 184.8 °C
• Appearance: /
• Density: 1.345 g/cm³
• CAS DataBase Reference: 4'-HYDROXY-3,4-METHYLENEDIOXYCHALCONE(CAS DataBase Reference)
• NIST Chemistry Reference: 4'-HYDROXY-3,4-METHYLENEDIOXYCHALCONE(19152-39-7)
• EPA Substance Registry System: 4'-HYDROXY-3,4-METHYLENEDIOXYCHALCONE(19152-39-7)

Safety Data

• Hazard Codes: Xi
• HazardClass: IRRITANT
• Hazardous Substances Data: 19152-39-7(Hazardous Substances Data)

Usage

General Description

4'-HYDROXY-3,4-METHYLENEDIOXYCHALCONE is a chemical compound that belongs to the chalcone family. It is a natural flavonoid found in plants such as Angelica keiskei, also known as Ashitaba. 4'-HYDROXY-3,4-METHYLENEDIOXYCHALCONE has been studied for its potential pharmacological properties, including anti-inflammatory, antioxidant, and anti-cancer effects. It has also been shown to inhibit the activity of certain enzymes and pathways involved in the progression of diseases such as cancer and diabetes. 4'-HYDROXY-3,4-METHYLENEDIOXYCHALCONE shows promise as a potential therapeutic agent and is the subject of ongoing research for its potential medical applications.

Upstream product

• 120-57-0 piperonal 
• 99-93-4 4-Hydroxyacetophenone 

Downstream Products

• 40135-87-3 4-(3-(benzo[d][1,3]dioxol-5-yl)propyl)phenol 
• 5937-86-0 4'-(2-hydroxy-ethoxy)-3,4-methylenedioxy-trans-chalcone 
• 169804-36-8 2-(1,3-benzodioxol-5-yl)-1-(4-isopropoxyphenyl)-4-oxobutyric acid methyl ester 
• 169804-35-7 2-(1,3-benzodioxol-5-yl)-1-(4-isopropoxyphenyl)-4-oxobutyronitrile 
• 689266-55-5 4'-(2,3-epoxypropoxy)-3,4-methylenedioxychalcone 

Relevant articles and documents

New class of hybrids based on chalcone and melatonin: a promising therapeutic option for the treatment of colorectal cancer

Considering that conventional chemotherapy provides only a limited increase of overall survival for patients with colorectal cancer (CRC), and resistance is a major cause of therapeutic failure, the emergence of new therapies is needed. Development of dif

Synthesis and Pharmacological Evaluation of 4-Aryloxyquinazoline Derivatives as Potential Cytotoxic Agents

In the present study, novel 4-aryloxyquinazoline derivatives were synthesized and screened for in vitro cytotoxicity on human cancer cell lines at 10 μM. Some of the synthesized compounds displayed moderate to significant and selective cytotoxic activity

Design, synthesis and antitumor activity of novel artemisinin derivatives using hybrid approach

In an attempt to develop potent and selective anti-tumor agents, two novel series of artemisinin-chalcone hybrids were designed, synthesized and screened for their antitumor activities against HT-29, A549, MDA-MB-231, HeLa and H460 cell lines in vitro. Nearly all of the tested compounds showed significantly increased anti-tumor activity compared with the corresponding dihydroartemisinin (DHA). Most of the title compounds displayed good selectivity toward HT-29 and HeLa cell lines with IC50 values ranging from 0.09 to 0.85μM. Among them, the most promising compound 9c (IC50 range of 0.09-0.93μM) was 10.5- to 70-times more active than DHA (IC50 range of 5.6-15.6μM) respectively.