19152-39-7

Usage

Uses

Used in Pharmaceutical Industry:
4'-HYDROXY-3,4-METHYLENEDIOXYCHALCONE is used as a potential therapeutic agent for its anti-inflammatory, antioxidant, and anti-cancer properties. It modulates various signaling pathways and enzyme activities involved in the progression of diseases, offering a promising approach for the treatment of conditions such as cancer and diabetes.
Used in Nutraceutical Industry:
4'-HYDROXY-3,4-METHYLENEDIOXYCHALCONE is used as a natural supplement for its health-promoting properties. Its antioxidant and anti-inflammatory effects contribute to overall well-being and may help prevent the onset of certain diseases.
Used in Cosmetic Industry:
4'-HYDROXY-3,4-METHYLENEDIOXYCHALCONE is used as an active ingredient in cosmetic products for its potential skin health benefits. Its antioxidant properties may help protect the skin from environmental damage and promote a youthful appearance.
Used in Research and Development:
4'-HYDROXY-3,4-METHYLENEDIOXYCHALCONE is used as a subject of ongoing research to explore its potential medical applications and further understand its pharmacological properties. This research aims to develop new therapeutic strategies and improve existing treatments for various diseases.

Upstream product

• 120-57-0 piperonal 
• 99-93-4 4-Hydroxyacetophenone 

Downstream Products

• 689266-55-5 4'-(2,3-epoxypropoxy)-3,4-methylenedioxychalcone 
• 5937-86-0 4'-(2-hydroxy-ethoxy)-3,4-methylenedioxy-trans-chalcone 
• 40135-87-3 4-(3-(benzo[d][1,3]dioxol-5-yl)propyl)phenol 
• 169804-36-8 2-(1,3-benzodioxol-5-yl)-1-(4-isopropoxyphenyl)-4-oxobutyric acid methyl ester 
• 169804-35-7 2-(1,3-benzodioxol-5-yl)-1-(4-isopropoxyphenyl)-4-oxobutyronitrile 

Relevant academic research and scientific papers

New class of hybrids based on chalcone and melatonin: a promising therapeutic option for the treatment of colorectal cancer

Considering that conventional chemotherapy provides only a limited increase of overall survival for patients with colorectal cancer (CRC), and resistance is a major cause of therapeutic failure, the emergence of new therapies is needed. Development of dif

An environment-friendly synthesis of piperonal chalcones and their cytotoxic and antioxidant evaluation

Background: Grindstone technique has been widely used as an efficient, consistent, more environmentally benign, solvent-free protocol for the preparation of many compounds with higher atom economy. Methods: A series of fourteen piperonal chalcone compound

Synthesis and Pharmacological Evaluation of 4-Aryloxyquinazoline Derivatives as Potential Cytotoxic Agents

In the present study, novel 4-aryloxyquinazoline derivatives were synthesized and screened for in vitro cytotoxicity on human cancer cell lines at 10 μM. Some of the synthesized compounds displayed moderate to significant and selective cytotoxic activity

Synthesis and biological evaluation of chalcone, dihydrochalcone, and 1,3-diarylpropane analogs as anti-inflammatory agents

Twenty-one chalcones were prepared via aldol condensation and subsequent reduction of these compound led to the corresponding dihydrochalcone and 1,3-diphenylpropane derivatives. The synthetic products were examined for their effects on NO inhibition in L

Design, synthesis and antitumor activity of novel artemisinin derivatives using hybrid approach

In an attempt to develop potent and selective anti-tumor agents, two novel series of artemisinin-chalcone hybrids were designed, synthesized and screened for their antitumor activities against HT-29, A549, MDA-MB-231, HeLa and H460 cell lines in vitro. Nearly all of the tested compounds showed significantly increased anti-tumor activity compared with the corresponding dihydroartemisinin (DHA). Most of the title compounds displayed good selectivity toward HT-29 and HeLa cell lines with IC50 values ranging from 0.09 to 0.85μM. Among them, the most promising compound 9c (IC50 range of 0.09-0.93μM) was 10.5- to 70-times more active than DHA (IC50 range of 5.6-15.6μM) respectively.

Synthesis and antidyslipidemic activity of chalcone fibrates

A series of chalcone based PPAR-α agonists were synthesized and evaluated for their antidyslipidemic activity in high fructose high fat fed dyslipidemic Syrian golden hamsters. Most of the compounds exhibited antidyslipidemic activity. The compounds 4c an

Synthesis of a series of novel dihydroartemisinin derivatives containing a substituted chalcone with greater cytotoxic effects in leukemia cells

Fifteen dihydroartemisinin derivatives containing a substituted chalcone linked by either ether or ester were synthesized and investigated for their cytotoxicity in human leukemia HL-60 and mouse lymphoma P388 cells. These derivatives have greater antiproliferative and cytotoxic effects in both cell lines than dihydroartemisinin. Dihydroartemisinin chalcones linked by ether are more cytotoxic than dihydroartemisinin chalcones linked by ester with apoptosis induction abilities.

Synthesis and fungicidal evaluation of novel chalcone-based strobilurin analogues

Strobilurin derivatives have become one of the most important classes of agricultural fungicide due to a novel action mode, wide fungicidal spectrum, lower toxicity toward mammalian cells, and environmentally benign characteristics. To discover new strobilurin analogues with high activity against resistant pathogens, a series of new chalcone-based strobilurin derivatives are designed and synthesized by integrating a chalcone scaffold with a strobilurin pharmacophore. The preliminary bioassay showed that some of the chalcone analogues exhibited good in vivo fungicidal activities against Pseudoperoniospora cubensis and Sphaerotheca fuliginea at the dosage of 200 μg mL-1. Two compounds, (￡)-methyl 2-[2-({3-[(￡)-3-(2- chlorophenyl)acryloyl]phenoxy}methyl)phenyl]-3-meth-oxyacrylate (1e) and (E)-methyl 2-[2-({3-[(E)-3-(3-bromophenyl)acryloyl]phenoxy}methyl)phenyl]-3- methoxyacrylate (11), were found to display higher fungicidal activities against P. cubensis (EC90 = 118.52 μg ml-1 for 1e and EC 90 = 113.64 μg mL-1 for 11) than Kresoxim-methyl (EC90 = 154.92 μg mL-1) and were identified as the most promising candidates for further study. The present work demonstrated that strobilurin analogues containing chalcone as a side chain could be used as a lead structure for further developing novel fungicides. To our knowledge, this is the first report about the syntheses and fungicidal activities of chalcone-based strobilurin derivatives.

Oxy substituted chalcones as antihyperglycemic and antidyslipidemic agents

The present invention provides novel substituted chalcone derivatives which exhibit anti-hyperglycemic and anti-dyslipedemic activity. The invention also provides a method for treating type II diabetes and associated hyperlipidemic conditions in a mammal

Synthesis and antihyperglycemic activity of chalcone based aryloxypropanolamines

A series of aryloxypropanolamines (5a-r) of different chalcones (3a-e) were synthesized and evaluated for antihyperglycemic activity in sucrose loaded (SLM) and streptozotocin (STZ) induced diabetic animal models. Among them compounds 5a, g, m, o, p and r