191596-48-2Relevant academic research and scientific papers
Enantioselective acyclic stereoselection under catalyst control. 2. Asymmetric synthesis of syn- and anti-1,3-diols incorporating an acetate equivalent by the chiral oxarzaborolidinone-catalyzed aldol reaction
Kiyooka, Syun-Ichi,Yamaguchi, Takafumi,Maeda, Hirofumi,Kira, Haruhide,Hena, Mostofa Abu,Horiike, Michio
, p. 3553 - 3556 (1997)
The chiral oxazaborolidinone-catalysed aldol reaction of a silyl ketene acetal involving a dithiolane moiety with β-silyloxy aldehyde resulted in the production of syn- and anti-1,3-diols with complete stereoselection by the choice of the stereochemistry of the catalyst. This reaction is an elegant example of enantioselective acyclic stereoselection under catalyst control.
Substituted pyranone inhibitors of cholesterol synthesis
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, (2008/06/13)
The methyl, ethyl, n-propy, 2-(acetylamino)ethyl, or 1-(2,3-dihydroxy)propyl ester of E-(3R,5S)-7-(4'-fluoro-3,3',5-trimethyl[1,1'-biphenyl]-2-yl)-3,5-dihydroxy-6-heptenoic acid of structural formula: STR1 are HMG-CoA reductase inhibitors useful in the treatment of conditions associated with hypercholesterolemia.
Substituted pyranone inhibitors of cholesterol synthesis
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, (2008/06/13)
6-Phenyl-, phenylalkyl- and phenylethenyl-4-hydroxytetrahydropyran-2-ones in the 4(R)-trans stereoisomeric forms are potent inhibitors of cholesterol synthesis by virtue of their ability to inhibit the enzyme, 3-hydroxy-3-methylglutaryl-coenzyme A reductase.
SUBSTITUTED PYRANONE INHIBITORS OF CHOLESTEROL SYNTHESIS
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, (2008/06/13)
6-Phenyl-, phenylalkyl-and phenylethenyl-4-hydroxytetrahydropyran-2-ones in the 4(R)-trans stereoisomeric forms are potent inhibitors of cholesterol synthesis by virtue of their ability to inhibit the enzyme, 3-hydroxy-3-methylglutaryl-coenzyme A reductas
