191610-54-5

Upstream product

• 138871-58-6 (S)-2-(tert-butyl-diphenyl-silanyloxymethyl)-5-oxo-2,5-dihydro-pyrrole-1-carboxylic acid tert-butyl ester 
• 138509-45-2 4-bromo-2-cyclopentyloxyanisole 
• 90-05-1 2-methoxy-phenol 
• 37942-01-1 5-bromo-2-methoxyphenol 
• 531-37-3 2-methoxyphenyl benzoate 
• 137-43-9 Cyclopentyl bromide 

Downstream Products

• 191610-55-6 (4R,5S)-1-tert-butoxycarbonyl-4-(3-cyclopentyloxy-4-methoxyphenyl)-5-hydroxymethylpyrrolidin-2-one 
• 85416-75-7 (R)-4-(3-cyclopentyloxy-4-methoxyphenyl)pyrrolidin-2-one 
• 191610-56-7 (2S,3R)-1-tert-butoxycarbonyl-3-(3-cyclopentyloxy-4-methoxyphenyl)-5-oxopyrrolidine-2-carboxylic acid 

Relevant academic research and scientific papers

A stereoselective synthesis of (R)-(-)-rolipram from L-glutamic acid

A stereoselective synthesis of (R)-(-)-rolipram from L-glutamic acid is described. The key step is a stereoselective Michael addition of an arylcuprate to a modified pyroglutamic derivative which acts as the template to induce the stereoselectivity. Facile manipulation of the enantiomerically pure Michael product afforded the expected therapeutic agent.