A stereoselective synthesis of (R)-(-)-rolipram from L-glutamic acid

DOI: 10.1055/s-1997-3182

Source and publish data:

Synthesis p. 559 - 562 (1997)

Update date:2022-08-03

Topics:

Authors:

Diaz, Adolfo

Siro, Jorge G.

García-Navío, José L.

Vaquero, Juan J.

Alvarez-Builla, Julio

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Article abstract of DOI:10.1055/s-1997-3182

A stereoselective synthesis of (R)-(-)-rolipram from L-glutamic acid is described. The key step is a stereoselective Michael addition of an arylcuprate to a modified pyroglutamic derivative which acts as the template to induce the stereoselectivity. Facile manipulation of the enantiomerically pure Michael product afforded the expected therapeutic agent.

Full text of DOI:10.1055/s-1997-3182

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