191611-56-0

Basic information

• Product Name: ethyl 2,2-dimethyl-4-oxochromane-7-carboxylate
• CAS NO: 191611-56-0
• Molecular Weight: 248.279
• Mol File: 191611-56-0.mol
• Article Data: 3

Chemical Properties

• Boiling Point: 374.8±41.0 °C(Predicted)
• Density: 1.146±0.06 g/cm3(Predicted)
• CAS DataBase Reference: ethyl 2,2-dimethyl-4-oxochromane-7-carboxylate(CAS DataBase Reference)
• NIST Chemistry Reference: ethyl 2,2-dimethyl-4-oxochromane-7-carboxylate(191611-56-0)
• EPA Substance Registry System: ethyl 2,2-dimethyl-4-oxochromane-7-carboxylate(191611-56-0)

Safety Data

• Hazardous Substances Data: 191611-56-0(Hazardous Substances Data)

Upstream product

• 934388-20-2 ethyl 4-acetyl-3-hydroxybenzoate 
• 67-64-1 acetone 
• 102297-62-1 3-hydroxy-4-(1-oxo-ethane)benzoic acid 
• 6304-89-8 3-acetoxybenzoic acid 
• 17771-33-4 7-hydroxy-2,2-dimethyl-chroman-4-one 
• 64-17-5 ethanol 
• 201230-82-2 carbon monoxide 
• 897921-78-7 2,2-dimethyl-7-(trifluoromethylsulfonyloxy)chromanone 

Downstream Products

• 1393844-52-4 N-(2-aminophenyl)-2-(2-chloro-6-fluorophenyl)-4,4-dimethyl-1,4-dihydrochromeno[3,4-d]imidazole-7-carboxamide 
• 1393843-93-0 ethyl 2-(2-chloro-6-fluorophenyl)-4,4-dimethyl-1,4-dihydrochromeno[3,4-d]imidazole-7-carboxylate 
• 1393843-91-8 2-(2-chloro-6-fluorophenyl)-4,4-dimethyl-1,4-dihydrochromeno[3,4-d]imidazole-7-carboxylic acid 
• 1393843-05-4 2-(2-chloro-6-fluorophenyl)-4,4-dimethyl-N-[4-(trifluoromethyl)phenyl]-1,4-dihydrochromeno[3,4-d]imidazole-7-carboxamide 
• 1393843-20-3 2-(2-chloro-6-fluorophenyl)-4,4-dimethyl-N-(4-methylthiazol-2-yl)-1,4-dihydrochromeno[3,4-d]imidazole-7-carboxamide 
• 1393843-04-3 7-(1H-benzo[d]imidazol-2-yl)-2-(2-chloro-6-fluorophenyl)-4,4-dimethyl-1,4-dihydrochromeno[3,4-d]imidazole 
• 1393843-02-1 2-(2-chloro-6-fluorophenyl)-7-(3-cyclopropyl-1,2,4-oxadiazol-5-yl)-4,4-dimethyl-1,4-dihydro-chromeno[3,4-d]imidazole 

Relevant articles and documents

Synthesis and biological activity of cyclic analogues of MPPG and MCPG as metabotropic glutamate receptor antagonists

The synthesis of two rigidified phenylglycine analogues is disclosed. The cyclic analogue 1 of (R,S)-α-methyl-4-phosphonophenylglycine (MPPG) is shown to be a particularly interesting pharmacological tool, for it is a group II selective mGluR antagonist that possesses an inverse agonist-like action.

TRICYCLIC COMPOUNDS AS mPGES-1 INHIBITORS

The present invention relates to tricyclic compounds of formula (I) or pharmaceutically acceptable salt thereof as mPGES-1 inhibitors. These compounds are inhibitors of the microsomal prostaglandin E synthase-1 (mPGES-1) enzyme and are therefore useful in the treatment of pain and/or inflammation from a variety of diseases or conditions, such as asthama, osteoarthritis, rheumatoid arthritis, acute or chronic pain and neurodegenerative diseases. (I)