19166-62-2

Usage

Uses

Used in Pharmaceutical Industry:
(Hydroxyimino)malononitrile sodium salt is used as a synthetic precursor for the development of various pharmaceuticals. Its water solubility and reactivity make it an ideal candidate for the production of a broad spectrum of medicinal compounds, contributing to the advancement of healthcare solutions.
Used in Agrochemical Industry:
In the agrochemical sector, (hydroxyimino)malononitrile sodium salt is utilized as a starting material for the synthesis of different agrochemicals. Its role in creating effective pesticides and other agricultural products highlights its importance in ensuring crop protection and yield enhancement.
Used in Organic Synthesis:
(Hydroxyimino)malononitrile sodium salt is employed as a fundamental building block in organic synthesis. Its versatile chemical properties allow it to be a key component in the creation of a diverse range of organic compounds, facilitating advancements in chemical research and product development across various industries.

Upstream product

• 109-77-3 malononitrile 

Downstream Products

• 20893-01-0 ({[(4-methylphenyl)sulfonyl]oxy}imino)malononitrile 
• 321592-13-6 C₁₆H₁₃N₃O₂ 
• 1346257-80-4 (2,4-dinitrophenoxyimino)malononitrile 

Relevant academic research and scientific papers

Oxidation of: O -dioxime by (diacetoxyiodo)benzene: Green and mild access to furoxans

Furoxan has been widely used in the field of high energy density materials because of its excellent properties such as high density, high standard enthalpy of formation and high nitrogen content. However, its existing synthesis methods are still restricted by the problems of difficult substrate preparation and manual handling of hazardous reagents. Herein, we disclosed a mild oxidation strategy to efficiently obtain furoxan derivatives starting from readily available o-dioxime substrates. This reaction features high functional group tolerance and easy scale-up, and has excellent regioselectivity for specific nonsymmetric o-dioximes. This method greatly reduces the safety risk and simplifies the operation process, and means that diversified furoxan derivatives can be easily accessed, thus paving the way for the wide application of furoxan derivatives. This journal is

Method for synthesizing 3-cyano-4-nitrofuroxan

The invention discloses a method for synthesizing 3-cyano-4-nitrofuroxan.The method includes the following steps that firstly, malononitrile and sodium nitrite are added into water under stirring and at the temperature of -5-0 DEG C, then glacial acetic acid is added dropwise, the temperature is increased to 10-25 DEG C, reaction is conducted for 3-5 h, and malononitrile oxime sodium salt is obtained; secondly, under stirring, the malononitrile oxime sodium salt is added into anhydrous ethanol, then hydroxylamine hydrochloride is added, heating is conducted after addition till reflux reaction is conducted for 3-6 h, and 1-amino-2-cyano dioxime is obtained; thirdly, under stirring, 1-amino-2-cyano dioxime is dissolved in diethyl ether, glacial acetic acid and lead dioxide are added, reaction is conducted for 3-5 h at the temperature of 10-25 DEG C, and 3-cyano-4-aminofuroxan is obtained; fourthly, under stirring, concentrated sulfuric acid is slowly added into a sodium tungstate dehydrate and 30% hydrogen peroxide slowly at the temperature of -10-0 DEG C, the temperature is increased to 20-35 DEG C after addition, then 3-cyano-4-aminofuroxan is added in batches, the temperature of 25-35 DEG C is preserved after addition, reaction is conducted for 2-3 h, and 3-cyano-4-nitrofuroxan is obtained.The method is mainly used for synthesizing 3-cyano-4-nitrofuroxan.

Condensations with Oxime O-Sulfonates, I. - Synthesis of 2-Amino-4,5-dihydro-4,5-diimino-1H-pyrrole-3-carboxylates

The reaction of the oxime O-tosylates 1 with amidinoacetic acid esters 2 does not lead to the expected pyrazines 4, but rather to the novel 4,5-dihydro-1H-pyrrole-3-carboxylates 8 (= 2-pyrroline-3-carboxylates) by rearrangement via 7.The hydrolysis of the pyrroles 8 and their reactions with amines have been studied.