191729-21-2 Usage
Uses
Used in Pharmaceutical Synthesis:
2-Chloro-4-(phenylthio)pyrimidine is utilized as an intermediate in the synthesis of pharmaceuticals, contributing to the development of new drugs with potential therapeutic applications. Its unique structure allows for further functionalization and modification, facilitating the creation of diverse medicinal compounds.
Used in Agrochemical Synthesis:
In the agrochemical industry, 2-chloro-4-(phenylthio)pyrimidine serves as an intermediate for the synthesis of various agrochemicals, including pesticides and herbicides. Its incorporation into these products can enhance their effectiveness in controlling pests and weeds, thereby improving crop yields and quality.
Used as a Building Block for Organic Synthesis:
Beyond its applications in pharmaceuticals and agrochemicals, 2-chloro-4-(phenylthio)pyrimidine is also employed as a building block for the preparation of other functionalized pyrimidine derivatives. Its reactivity and structural features make it a useful component in the synthesis of a wide range of organic compounds with various applications in different industries.
Check Digit Verification of cas no
The CAS Registry Mumber 191729-21-2 includes 9 digits separated into 3 groups by hyphens. The first part of the number,starting from the left, has 6 digits, 1,9,1,7,2 and 9 respectively; the second part has 2 digits, 2 and 1 respectively.
Calculate Digit Verification of CAS Registry Number 191729-21:
(8*1)+(7*9)+(6*1)+(5*7)+(4*2)+(3*9)+(2*2)+(1*1)=152
152 % 10 = 2
So 191729-21-2 is a valid CAS Registry Number.
InChI:InChI=1/C10H7ClN2S/c11-10-12-7-6-9(13-10)14-8-4-2-1-3-5-8/h1-7H
191729-21-2Relevant academic research and scientific papers
HFIP Promoted Low-Temperature SNAr of Chloroheteroarenes Using Thiols and Amines
Bhujabal, Yuvraj B.,Vadagaonkar, Kamlesh S.,Gholap, Aniket,Sanghvi, Yogesh S.,Dandela, Rambabu,Kapdi, Anant R.
, p. 15343 - 15354 (2019/12/04)
A highly efficient and an unprecedented hexafluoro-2-propanol, promoting low-temperature aromatic nucleophilic substitutions of chloroheteroarenes, has been performed using thiols and (secondary) amines under base-free and metal-free conditions. The developed protocol also provides excellent regio-control for the selective functionalization of dichloroheteroarenes, while the utility of the protocol was demonstrated by the modification of a commercially available drug ceritinib.
THIOPYRIMIDINE-BASED COMPOUNDS AND USES THEREOF
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Page/Page column 101, (2008/12/07)
The present invention relates to thiopyrimidine-based compounds that are inhibitors of protein kinases including JAK kinases. In particular, the compounds are selective for JAK1, JAK2 or JAK3 kinases and combinations thereof such as JAK1 and JAK2. The kinase inhibitors can be used in the treatment of kinase associated diseases such as immunological and inflammatory diseases including organ transplants; hyperproliferative diseases including cancer and myeloproliferative diseases; viral diseases; metabolic diseases and vascular diseases.
