19178-32-6

Upstream product

• 1397833-86-1 (2-amino-4,5-dimethoxyphenyl)(benzotriazole-1-yl)methanone 
• 74-89-5 methylamine 
• 4998-07-6 4,5-dimethoxy-2-nitro-benzoic acid 
• 5653-40-7 2-Amino-4,5-dimethoxybenzoic acid 
• 19178-31-5 4,5-Dimethoxy-N-methyl-2-nitro-benzamide 

Relevant academic research and scientific papers

A new protocol for the synthesis of primary, secondary and tertiary anthranilamides utilizing N-(2-aminoarylacyl)benzotriazoles

A convenient route for efficient conversion of unprotected anthranilic acids into the corresponding N-(2-aminoarylacyl)benzotrazoles is described. N-(2-Aminoarylacyl)-benzotrazoles have been successfully used to synthesize primary, secondary and tertiary anthranilamides in high yields (71-96%). ARKAT-USA, Inc.

HETEROAROMATIC QUINOLINE-BASED COMPOUNDS

The invention pertains to heteroaromatic compounds that serve as effective phosphodiesterase (PDE) inhibitors. The invention also relates to compounds which are selective inhibitors of PDE10. The invention further relates to intermediates for preparation of such compounds; pharmaceutical compositions comprising such compounds; and the use of such compounds in methods for treating certain central nervous system (CNS) or other disorders. The invention relates also to methods for treating neurodegenerative and psychiatric disorders, for example psychosis and disorders comprising deficient cognition as a symptom.

Synthesis and structure-activity relationship of diarylamide derivatives as selective inhibitors of the proliferation of human coronary artery smooth muscle cells

A series of diarylamide derivatives were synthesized and evaluated for their inhibitory activities against human coronary artery smooth muscle cells (SMCs) and human coronary artery endothelial cells (ECs). Compound 2w was superior to the lead compound, Tranilast, in terms of the potency of the activity and cell selectivity.

Therapeutic piperazinylalkyl-quinazolone-(4)-derivatives

Aryl-substituted piperazinylalkyl-quniazolone-(4) derivatives suitable forse as hypotensive, antihistaminic, and analgesic drugs are described. Process for the preparation of the compounds by (1) intra molecular condensation of the product obtained from t