191793-95-0

Upstream product

• 39576-24-4 2,2-dimethyl-1-phenyl-4-pentene 
• 100-63-0 phenylhydrazine 

Downstream Products

• 1616560-29-2 4,4-dimethyl-1,3-diphenyl-5-vinyl-4,5-dihydro-1H-pyrazole 
• 1616560-30-5 1,1'-((1-(4,4-dimethyl-1,3-diphenyl-4,5-dihydro-1H-pyrazol-5-yl)ethane-1,2-diyl)bis-(oxy))bis(2,2,6,6-tetramethylpiperidine) 

Relevant academic research and scientific papers

Synthesis of Tetrahydropyridazines via Pd-Catalyzed Carboamination of Alkenyl Hydrazones

We report herein a facile approach to tetrahydropyridazines, a scaffold found in many natural products and biologically active entities, via Pd-catalyzed carboamination of readily available alkenyl hydrazones with aryl and alkenyl halides. Preliminary studies showed its promise for enantioselective synthesis. This work offers an expedient access to the tetrahydropyridazine scaffold bearing substitution patterns, thus significantly increasing the availability of these derivatives for downstream evaluation.

TEMPO-mediated allylic C-H amination with hydrazones

TEMPO-mediated reactions of alkenyl hydrazones afforded azaheterocycles via sp3 C-H allylic amination. The transformation is featured by a sequence of remote allylic H-radical shift and allylic homolytic substitution with hydrazone radicals. This journal is