191801-94-2Relevant academic research and scientific papers
Synthesis and antiproliferative evaluation of certain indeno[1,2-c]quinoline derivatives
Tseng, Chih-Hua,Chen, Yeh-Long,Lu, Pei-Jung,Yang, Chia-Ning,Tzeng, Cherng-Chyi
, p. 3153 - 3162 (2008)
Although the quinoline ring is found in a wide variety of biologically active compounds and is frequently condensed with various heterocycles, synthesis and biological evaluation of the indenoquinoline skeleton attracts only very limited attention. We rep
Histone deacetylase inhibitor based on indenoquinolone skeleton and preparation method and application thereof
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Paragraph 0047; 0048; 0049; 0050; 0051; 0052, (2017/08/25)
The invention discloses a histone deacetylase inhibitor based on indenoquinolone skeleton and a preparation method and application thereof. The compound has a structure as shown in the general formula (I) or (II). The compound of the invention has strong
INDENOQUINOLONE COMPOUND, PREPARATION METHOD AND USE THEREOF
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, (2013/04/10)
An indenoquinolone compounds of Formula (A) is disclosed, wherein the definition of each group is described in the description. These compounds may specifically inhibit topoisomerase I, and they have good activities against many kinds of human tumor cells, such as lung cancer, colon cancer, breast cancer, liver cancer and the like. They can be used in the manufacture of antitumor drugs. The method for preparing the compound of formula (A), and pharmaceutical compositions containing such compounds and the use in the manufacture of antitumor drugs are also disclosed.
