Cas 191846-71-6,5-(Aziridin-1-yl)-3-(hydroxymethyl)-1,2-dimethyl-4,7-dihydro-1H-indole-4,7-dione

191846-71-6

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Basic information

Product Name: 5-(Aziridin-1-yl)-3-(hydroxymethyl)-1,2-dimethyl-4,7-dihydro-1H-indole-4,7-dione
Synonyms:
CAS NO:191846-71-6
Molecular Formula: C₁₃H₁₄N₂O₃
Molecular Weight: 246.26813
EINECS: N/A
Product Categories: N/A
Mol File: 191846-71-6.mol

Chemical Properties

Melting Point: N/A
Boiling Point: N/A
Flash Point: N/A
Appearance: N/A
Density: N/A
Refractive Index: N/A
Storage Temp.: N/A
Solubility: N/A
CAS DataBase Reference: 5-(Aziridin-1-yl)-3-(hydroxymethyl)-1,2-dimethyl-4,7-dihydro-1H-indole-4,7-dione(CAS DataBase Reference)
NIST Chemistry Reference: 5-(Aziridin-1-yl)-3-(hydroxymethyl)-1,2-dimethyl-4,7-dihydro-1H-indole-4,7-dione(191846-71-6)
EPA Substance Registry System: 5-(Aziridin-1-yl)-3-(hydroxymethyl)-1,2-dimethyl-4,7-dihydro-1H-indole-4,7-dione(191846-71-6)

Safety Data

Hazard Codes: N/A
Statements: N/A
Safety Statements: N/A
WGK Germany:
RTECS:
HazardClass: N/A
PackingGroup: N/A
Hazardous Substances Data: 191846-71-6(Hazardous Substances Data)

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Check Digit Verification of cas no

The CAS Registry Mumber 191846-71-6 includes 9 digits separated into 3 groups by hyphens. The first part of the number,starting from the left, has 6 digits, 1,9,1,8,4 and 6 respectively; the second part has 2 digits, 7 and 1 respectively.
Calculate Digit Verification of CAS Registry Number 191846-71:
(8*1)+(7*9)+(6*1)+(5*8)+(4*4)+(3*6)+(2*7)+(1*1)=166
166 % 10 = 6
So 191846-71-6 is a valid CAS Registry Number.

191846-71-6Upstream product

191846-71-6Downstream Products

191846-71-6Relevant academic research and scientific papers

Indolequinone antitumor agents: Relationship between quinone structure and rate of metabolism by recombinant human NQO1

Beall, Howard D.,Hudnott, Anna R.,Winski, Shannon,Siegel, David,Swann, Elizabeth,Ross, David,Moody, Christopher J.

, p. 545 - 548 (1998)

A series of indolequinones bearing various functional groups has been synthesized, and the effects of substituents on the metabolism of the quinones by recombinant human NAD(P)H:quinone oxidoreductase (NQO1), and on the toxicity toward nonsmall cell lung cancer cells with either high NQO1 activity (H460) or with no detectable activity (H596) were studied.

Indolequinone antitumor agents: Correlation between quinone structure, rate of metabolism by recombinant human NAD(P)H:quinone oxidoreductase, and in vitro cytotoxicity

Beall, Howard D.,Winski, Shannon,Swann, Elizabeth,Hudnott, Anna R.,Cotterill, Ann S.,O'Sullivan, Noeleen,Green, Stephen J.,Bien, Richard,Siegel, David,Ross, David,Moody, Christopher J.

, p. 4755 - 4766 (2007/10/03)

A series of indolequinones bearing various functional groups has been synthesized, and the effects of substituents on the metabolism of the quinones by recombinant human NAD(P)H: quinone oxidoreductase (NQO1) were studied. Thus 5-methoxyindolequinones wer

2-cyclopropylindoloquinones and their analogues as bioreductively activated antitumor agents: Structure-activity in vitro and efficacy in vivo

Naylor, Matthew A.,Jaffar, Mohammed,Nolan, John,Stephens, Miriam A.,Butler, Susan,Patel, Kantilal B.,Everett, Steven A.,Adams, Gerald E.,Stratford, Ian J.

, p. 2335 - 2346 (2007/10/03)

A series of 2-cycloalkyl- and 2-alkyl-3-(hydroxymethyl)-1- methylindoloquinones and corresponding carbamates have been synthesized and substituted in the 5-position with a variety of substituted and unsubstituted aziridines. Cytotoxicity against hypoxic c

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