191846-71-6

Basic information

• Product Name: 5-(Aziridin-1-yl)-3-(hydroxymethyl)-1,2-dimethyl-4,7-dihydro-1H-indole-4,7-dione
• CAS NO: 191846-71-6
• Molecular Formula: C₁₃H₁₄N₂O₃
• Molecular Weight: 246.26813
• Mol File: 191846-71-6.mol
• Article Data: 3

Chemical Properties

• CAS DataBase Reference: 5-(Aziridin-1-yl)-3-(hydroxymethyl)-1,2-dimethyl-4,7-dihydro-1H-indole-4,7-dione(CAS DataBase Reference)
• NIST Chemistry Reference: 5-(Aziridin-1-yl)-3-(hydroxymethyl)-1,2-dimethyl-4,7-dihydro-1H-indole-4,7-dione(191846-71-6)
• EPA Substance Registry System: 5-(Aziridin-1-yl)-3-(hydroxymethyl)-1,2-dimethyl-4,7-dihydro-1H-indole-4,7-dione(191846-71-6)

Safety Data

• Hazardous Substances Data: 191846-71-6(Hazardous Substances Data)

Upstream product

• 161518-23-6 1,2-dimethyl-3-formyl-5-methoxyindole-4,7-dione 
• 151-56-4 ethyleneimine 
• 161518-24-7 3-(hydroxymethyl)-5-methoxy-1,2-dimethyl-1H-indole-4,7-dione 
• 205177-88-4 5-Methoxy-1,2-dimethyl-4,7-dioxo-4,7-dihydro-1H-indole-3-carboxylic acid ethyl ester 

Relevant articles and documents

Indolequinone antitumor agents: Relationship between quinone structure and rate of metabolism by recombinant human NQO1

A series of indolequinones bearing various functional groups has been synthesized, and the effects of substituents on the metabolism of the quinones by recombinant human NAD(P)H:quinone oxidoreductase (NQO1), and on the toxicity toward nonsmall cell lung cancer cells with either high NQO1 activity (H460) or with no detectable activity (H596) were studied.

2-cyclopropylindoloquinones and their analogues as bioreductively activated antitumor agents: Structure-activity in vitro and efficacy in vivo

A series of 2-cycloalkyl- and 2-alkyl-3-(hydroxymethyl)-1- methylindoloquinones and corresponding carbamates have been synthesized and substituted in the 5-position with a variety of substituted and unsubstituted aziridines. Cytotoxicity against hypoxic c