Indolequinone antitumor agents: Relationship between quinone structure and rate of metabolism by recombinant human NQO1
A series of indolequinones bearing various functional groups has been synthesized, and the effects of substituents on the metabolism of the quinones by recombinant human NAD(P)H:quinone oxidoreductase (NQO1), and on the toxicity toward nonsmall cell lung cancer cells with either high NQO1 activity (H460) or with no detectable activity (H596) were studied.
Beall, Howard D.,Hudnott, Anna R.,Winski, Shannon,Siegel, David,Swann, Elizabeth,Ross, David,Moody, Christopher J.
Indolequinone antitumor agents: Correlation between quinone structure, rate of metabolism by recombinant human NAD(P)H:quinone oxidoreductase, and in vitro cytotoxicity
A series of indolequinones bearing various functional groups has been synthesized, and the effects of substituents on the metabolism of the quinones by recombinant human NAD(P)H: quinone oxidoreductase (NQO1) were studied. Thus 5-methoxyindolequinones wer
Beall, Howard D.,Winski, Shannon,Swann, Elizabeth,Hudnott, Anna R.,Cotterill, Ann S.,O'Sullivan, Noeleen,Green, Stephen J.,Bien, Richard,Siegel, David,Ross, David,Moody, Christopher J.
p. 4755 - 4766
(2007/10/03)
2-cyclopropylindoloquinones and their analogues as bioreductively activated antitumor agents: Structure-activity in vitro and efficacy in vivo
A series of 2-cycloalkyl- and 2-alkyl-3-(hydroxymethyl)-1- methylindoloquinones and corresponding carbamates have been synthesized and substituted in the 5-position with a variety of substituted and unsubstituted aziridines. Cytotoxicity against hypoxic c
Naylor, Matthew A.,Jaffar, Mohammed,Nolan, John,Stephens, Miriam A.,Butler, Susan,Patel, Kantilal B.,Everett, Steven A.,Adams, Gerald E.,Stratford, Ian J.
p. 2335 - 2346
(2007/10/03)
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