191846-76-1 Usage
General Description
5-METHOXY-1-METHYL-4-NITROINDOLE-3-CARBOXALDEHYDE is a chemical compound with the molecular formula C11H10N2O3. It is a nitroindole derivative and has a yellow crystalline appearance. 5-METHOXY-1-METHYL-4-NITROINDOLE-3-CARBOXALDEHYDE is used in organic synthesis and pharmaceutical research as a building block for creating other chemical structures. It has potential applications in the pharmaceutical industry due to its unique structural properties and the nitro group, which can be used as a key moiety in designing new drugs and pharmaceutical products. Additionally, its methoxy and methyl functional groups make it a valuable intermediate in the synthesis of a variety of organic compounds.
Check Digit Verification of cas no
The CAS Registry Mumber 191846-76-1 includes 9 digits separated into 3 groups by hyphens. The first part of the number,starting from the left, has 6 digits, 1,9,1,8,4 and 6 respectively; the second part has 2 digits, 7 and 6 respectively.
Calculate Digit Verification of CAS Registry Number 191846-76:
(8*1)+(7*9)+(6*1)+(5*8)+(4*4)+(3*6)+(2*7)+(1*6)=171
171 % 10 = 1
So 191846-76-1 is a valid CAS Registry Number.
InChI:InChI=1/C11H10N2O4/c1-12-5-7(6-14)10-8(12)3-4-9(17-2)11(10)13(15)16/h3-6H,1-2H3
191846-76-1Relevant articles and documents
PYRROLOBENZODIAZEPINE PRODRUGS AND ANTIBODY CONJUGATES THEREOF
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Page/Page column 176, (2018/03/06)
The invention relates generally to pyrrolobenzodiazepine monomer and dimer prodrugs having a glutathione-activated disulfide prodrug moiety, a DT-diaphorase-activated quinone prodrug moiety or a reactive oxygen species-activated aryl boronic acid or aryl boronic ester prodrug moiety. The invention further relates to pyrrolobenzodiazepine prodrug dimer-antibody conjugates.
INDQ/NO, a bioreductively activated nitric oxide prodrug
Sharma, Kavita,Iyer, Aishwarya,Sengupta, Kundan,Chakrapani, Harinath
, p. 2636 - 2639 (2013/07/19)
The design, synthesis, and development of INDQ/NO, a novel nitric oxide (NO) prodrug targeted by a bioreductive trigger, are described. INDQ/NO, an indolequinone-diazeniumdiolate is found to be metabolized to produce NO by DT-diaphorase, a bioreductive enzyme that is overexpressed in certain cancers and hypoxic tumors. Cell-based assays revealed that INDQ/NO induces DNA damage and is a potent inhibitor of cancer cell proliferation.
