19185-38-7Relevant academic research and scientific papers
Enantioselective Synthesis of anti -β-Hydroxy-α-amino Esters via an Organocatalyzed Decarboxylative Aldol Reaction
March, Taryn,Murata, Akihiro,Kobayashi, Yusuke,Takemoto, Yoshiji
supporting information, p. 1295 - 1299 (2017/06/27)
The first enantioselective decarboxylative aldol addition with α-amido-substituted malonic acid half oxyesters (MAHOs) is described. The combined use of a newly designed bifunctional sulfonamide catalyst with pentafluorobenzoic acid as an additive afforde
Stereoselective synthesis of dehydroamino acids using malonic acid half oxyester and aromatic aldehydes
Singjunla, Yuttapong,Colombano, Silvia,Baudoux, Jér?me,Rouden, Jacques
, p. 2369 - 2375 (2016/04/26)
An efficient and direct approach was developed for the synthesis of α,β-dehydroamino acid derivatives with a broad range of substrates. Amido-substituted Malonic Acid Half Oxyesters (MAHOs) have proven to be excellent partners of various aromatic aldehyde
Direct synthesis of β-hydroxy-α-amino acids via diastereoselective decarboxylative aldol reaction
Singjunla, Yuttapong,Baudoux, Jeroime,Rouden, Jacques
supporting information, p. 5770 - 5773 (2013/12/04)
A straightforward metal-free synthesis of anti-β-hydroxy-α-amino acids is described. The organic base-mediated decarboxylative aldol reaction of cheap, readily available α-amidohemimalonates with various aldehydes afforded under very mild conditions anti-β-hydroxy-α-amido esters in high yields and complete diastereoselectivity. Simple one-pot subsequent transformations enabled the corresponding anti-β-hydroxy-α-amino acids or in a few examples their syn diastereomers to be obtained directly using epimerization conditions.
