191857-96-2Relevant academic research and scientific papers
Constrained analogues of 2'-nor cyclic nucleoside monophosphates
Tse, H. L. Allan,Knight, David J.,Coates, Jonathan A. V.,Mansour, Tarek S.
, p. 1387 - 1392 (2007/10/03)
The synthesis of constrained analogues of 2'-nor-cyclic nucleosides monophosphates containing a thiomethylene tether was readily accomplished from the oxathiolane intermediate 4. The uracil, cytosine, and 5-bromocytosine spirophosphate analogues 22, 16, and 25 were inhibitory to HCMV replication in Flow 2002 cells.
