191925-82-3Relevant academic research and scientific papers
Malonic acid derivatives as sialyl Lewis X mimetics
Toepfer, Alexander,Kretzschmar, Gerhard,Schuth, Silke,Sonnentag, Michael
, p. 1317 - 1322 (1997)
Malonic acid derivatives designed as mimetics of the sialyl Lewis X determinant were synthesized. Their inhibitory potency for selectin mediated cell adhesion was evaluated in cell culture assays and in vivo. The receptor binding affinity for E- and P-selectins of simple mimetics was found to be comparable to the potency of the tetrasaccharide sialyl Lewis X.
