Malonic acid derivatives as sialyl Lewis X mimetics

DOI: 10.1016/S0960-894X(97)00214-X

Source and publish data:

Bioorganic and Medicinal Chemistry Letters p. 1317 - 1322 (1997)

Update date:2022-08-03

Topics:

Authors:

Toepfer, Alexander

Kretzschmar, Gerhard

Schuth, Silke

Sonnentag, Michael

Read Full Text PDF DownLoad Join now for total 90,000,000 free articles

Article abstract of DOI:10.1016/S0960-894X(97)00214-X

Malonic acid derivatives designed as mimetics of the sialyl Lewis X determinant were synthesized. Their inhibitory potency for selectin mediated cell adhesion was evaluated in cell culture assays and in vivo. The receptor binding affinity for E- and P-selectins of simple mimetics was found to be comparable to the potency of the tetrasaccharide sialyl Lewis X.

Full text of DOI:10.1016/S0960-894X(97)00214-X

Products guided by the article

Product name:(2S,3S,4R,5R,6S)-2-[(1R,2R)-2-(6-Allyloxy-hexyloxy)-cyclohexyloxy]-3,4,5-tris-benzyloxy-6-methyl-tetrahydro-pyran

Cas No:191925-82-3

R&D Labs maybe for 191925-82-3

Xinchang Yueding Chemical Co., Ltd.

Contact:86-571-56926323

Address:NO.90 BEIMENCHENGWAI CHENGGUAN TOWN XINCHANG
Shanghai Mintchem Development ., Ltd

Contact:0086 21 5190 8570

Address:R602,4#,89Nong, Mudan Road Pudong Shanghai China
New Forms

Contact:+31-24-3886056

Address:Binderskampweg 29 Unit 36
Weifang Adde Economic And Trade Co.,LTD.

Contact:86-536-8885548

Address:Room 1402,Wanda Plaza B Block,No.958,Yuanfei Road,Kuiwen District
Zhejiang Kente Chemical Co.,Ltd.

Contact:86-0576-87651912

Address:No.7, Fengxi West Road, Modern Industrial Zone

Relevant to this article

Doi:10.1080/10473289.2002.10470810
(1943)
Doi:10.1039/j39680000801
(1968)
Oxazinanones as chiral auxiliaries: Synthesis and evaluation in enolate alkylations and aldol reactions

Doi:10.1039/b604073j
(2006)
Regioselective addition of mixed-chalcogenide iron carbonyl clusters Fe₂(CO)₆(μ-EE′) (E ≠ E′, E, E′ = S, Se, Te) to a carbon-carbon triple bond activated by a metal carbene fragment.

Doi:10.1021/om9702237
(1997)
Reactions of (tert-butyldimethylsilyl)alkynes with IPy₂BF₄: Selective synthesis of novel head-to-head dimers [8]

Doi:10.1021/ja970108n
(1997)
Reactions of nitrosoarenes with nitrogen monoxide (nitric oxide) and nitrogen dioxide: Formation of diarylnitroxides

Doi:10.1002/ejoc.200800213
(2008)

Article Doi