Bioorganic and Medicinal Chemistry Letters p. 1317 - 1322 (1997)
Update date:2022-08-03
Topics:
Toepfer, Alexander
Kretzschmar, Gerhard
Schuth, Silke
Sonnentag, Michael
Malonic acid derivatives designed as mimetics of the sialyl Lewis X determinant were synthesized. Their inhibitory potency for selectin mediated cell adhesion was evaluated in cell culture assays and in vivo. The receptor binding affinity for E- and P-selectins of simple mimetics was found to be comparable to the potency of the tetrasaccharide sialyl Lewis X.
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