Malonic acid derivatives as sialyl Lewis X mimetics

DOI: 10.1016/S0960-894X(97)00214-X

Source and publish data:

Bioorganic and Medicinal Chemistry Letters p. 1317 - 1322 (1997)

Update date:2022-08-03

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Authors:

Toepfer, Alexander

Kretzschmar, Gerhard

Schuth, Silke

Sonnentag, Michael

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Article abstract of DOI:10.1016/S0960-894X(97)00214-X

Malonic acid derivatives designed as mimetics of the sialyl Lewis X determinant were synthesized. Their inhibitory potency for selectin mediated cell adhesion was evaluated in cell culture assays and in vivo. The receptor binding affinity for E- and P-selectins of simple mimetics was found to be comparable to the potency of the tetrasaccharide sialyl Lewis X.

Full text of DOI:10.1016/S0960-894X(97)00214-X

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