19196-63-5

Upstream product

• 4355-46-8 α-amino-α-methylphenylacetonitrile 
• 1086209-16-6 α-benzylideneamino-α-phenylacetamide 
• 74-88-4 methyl iodide 
• 565-07-1 2-amino-2-phenylpropanoic acid 
• 4507-40-8 2-(benzyloxycarbonylamino)-2-phenylpropanoic acid 
• 98-86-2 acetophenone 

Downstream Products

• 13398-26-0 (S)-2-methyl-2-phenylglycine 
• 29738-09-8 (R)-2-amino-2-phenylpropanoic acid 
• 152375-69-4 D-α-methyl-α-phenylglycinamide 
• 166538-41-6 2-(4-Nitrobenzoylamino)-2-phenylpropanamide 
• 30358-55-5 L-α-methylphenylglycine amide 

Relevant academic research and scientific papers

Substituent effect on acidity of substituted 2-(4-nitrobenzoylamino)alkanamidesin methanol-dimethyl sulfoxide mixtures

The dissociation constants of substituted 2-(4-nitrobenzoylamino)alkanamides, N-[2-(4-nitrobenzoylamino)aikanoyl]pyrrolidines, and N-alkyl-4-nitrobenzamides have been measured spectrophotometrically in 60 and 80% v/v DMSO. The pKA values of these N-acids are discussed from the point of view of substituents at the acetamide a-carbon atom.

Synthesis of α,α-Disubstituted α-Amino Acid Amides by Phase-Transfer Catalyzed Alkylation

α,α-Disubstituted α-amino acid amides were prepared in 17-88 percent chemical yield by the phase-transfer catalyzed alkylation of N-benzylidene α-H amino acid amides, followed by weak acidic hydrolysis of the Schiff bases.