191977-79-4

Usage

Uses

Used in Pharmaceutical Industry:
1,2-bis[3-(2-chloroethyl)benzimidazolin-2-one] is used as an impurity in Filbanserin, which is a medication developed to treat hypoactive sexual desire disorder in females. Its presence in Filbanserin may contribute to the overall efficacy and safety profile of the drug, and understanding its properties can help in optimizing the manufacturing process and ensuring the quality of the final product.

Upstream product

• 615-16-7 1,3-dihydro-2H-benzimidazol-2-one 
• 107-06-2 1,2-dichloro-ethane 

Relevant academic research and scientific papers

N,N'-Linked 1,2-ethanediyl-poly(benzimidazolin-2-ones) and the X-ray crystal structure of a benzimidazolin-2-one trimer

A series of N,N'-linked 1,2-ethanediyl-poly(benzimidazolin-2-ones) that can be classified as podands, are described. Seven dimers (21-27), three trimers (28-30), a cyclic tetramer (31) and an open-chain benzimidazolin-2-one heptamer (32) have been prepared and characterized by 1H, 13C NMR and by MS. The crystal and molecular structure of the trimer, 1,3-bis-2-(2-oxobenzimidazol-1-yl)ethyl-2-oxobenzimidazole monohydrate (30) has been solved by X-Ray analysis. The benzi-midazolin-2-one fragments display a pattern of bond distances and angles similar to that of analogue derivatives retrieved form the CSD. The molecules are hydrogen bonded to four others in a continuous two-dimensional network by N-H···O=C and C-H···O=C interactions in which all N-H donors and O=C accepters are involved.