191977-95-4

Upstream product

• 183295-17-2 5'-O-dimethoxytrityl-thymidine-3'-O-(2-seleno-1,3,2-dithiaphospholane) 
• 40615-39-2 5'-O-(4-4'-dimethoxytrityl)thymidine 
• 364356-56-9 3',5'-O,O-bis(dimethoxytrityl)-dithymidilyl-3',5'-Se-methyl phosphorothioselenoate 

Relevant academic research and scientific papers

Synthesis, chemical and enzymatic reactivity, and toxicity of dithymidylyl-3′,5′-phosphorofluoridate and -phosphorothiofluoridate

Dithymidylyl-3′,5′-phosphorofluoridate and phosphorothiofluoridate were obtained by fluorinolysis of the P-Se bond in appropriate bisidmethoxytrityl selenomethyl esters. These compounds, which are hydrolytically unstable, are not inhibitors of snake venom, spleen phosphodiesterases and alkaline phosphatase. Neither compound is highly toxic. Copyright

A new method for the formation of the P-F bond

Iodine-promoted desulfurization of phosphorothioate and phosphorodithioate diesters in the presence of triethylamine tris(hydrofluoride) (TAF) furnish a rapid and quantitative formation of the corresponding phosphorofluoridates and phosphorofluoridothioat