183295-17-2

Upstream product

• 145498-60-8 2-(N,N-diisopropylamino)-1,3,2-dithiaphospholane 
• 40615-39-2 5'-O-(4-4'-dimethoxytrityl)thymidine 

Downstream Products

• 183295-19-4 C₄₄H₄₉N₄O₁₃PSSe 
• 151852-35-6 C₄₄H₄₉N₄O₁₄PS 
• 191977-95-4 3',5'-O,O-bis(dimethoxytrityl)-dithymidilyl-3',5'-phosphorothiofluoridate 
• 364356-56-9 3',5'-O,O-bis(dimethoxytrityl)-dithymidilyl-3',5'-Se-methyl phosphorothioselenoate 

Relevant academic research and scientific papers

Synthesis, chemical and enzymatic reactivity, and toxicity of dithymidylyl-3′,5′-phosphorofluoridate and -phosphorothiofluoridate

Dithymidylyl-3′,5′-phosphorofluoridate and phosphorothiofluoridate were obtained by fluorinolysis of the P-Se bond in appropriate bisidmethoxytrityl selenomethyl esters. These compounds, which are hydrolytically unstable, are not inhibitors of snake venom, spleen phosphodiesterases and alkaline phosphatase. Neither compound is highly toxic. Copyright

Synthesis and Reactivity of Dithymidyl-3',5''-phosphorothiofluoridates

Based upon dithiaphospholane method the new approach to the synthesis of dithymidine-3',5''-phosphorothioselenoate (mixture of two P-diastereomers) was established.Methylation of these compounds occurred exclusively at selenium atom and obtained methylselenyl esters under treatment with fluoride ion gave dithymidine-3',5''-phosphorothiofluoridates as the mixtures of both P-stereoisomers.Their base-catalyzed hydrolysis and methanolysis led to dithymidine-3',5''-phosphorothioates and thymidine-3',5''-(O-methyl)phosphorothioates, respectively.