19198-68-6

Upstream product

• 2516-40-7 2-bromo-1,3-benzothiazole 
• 70-55-3 toluene-4-sulfonamide 
• 473-34-7 N,N-dichloro-p-toluenesulfonamide 
• 103-72-0 phenyl isothiocyanate 
• 136-95-8 2-amino-benzthiazole 
• 98-59-9 p-toluenesulfonyl chloride 

Downstream Products

• 1350554-14-1 (E)-N,3-ditosylbenzo[d]thiazol-2(3H)-imine 
• 1448592-51-5 bis-[N-(benzothiazol-2-yl)-4-methylbenzenesulphonamide]copper(I) chloride 
• 1448592-49-1 bis-[N-(benzothiazol-2-yl)-4-methylbenzenesulphonamide]dichlorocobalt(II) 
• 1448592-48-0 bis-[N-(benzothiazol-2-yl)-4-methylbenzenesulphonamide]dichloromanganese(II) 

Relevant academic research and scientific papers

Three-Component Ring-Opening Reactions of Cyclic Ethers, α-Diazo Esters, and Weak Nucleophiles under Metal-Free Conditions

A protocol for three-component reactions of cyclic ethers, α-diazo esters, and weak nitrogen, oxygen, carbon, and sulfur nucleophiles (pKa = 2.2-14.8) to afford a variety of structurally complex α-oxyalkylated esters is reported. These reactions involve intermolecular activation of the cyclic ether (present in excess) by the α-diazo ester to form an oxonium ylide under metal-free conditions, followed by ring opening by the nucleophile.

Syntheses, characterization and antimicrobial screening of N-(benzothiazol-2-yl)-4-methylbenzenesulphonamide and its Cu(I), Ni(II), Mn(II), Co(II) and Zn(II) complexes

N-(Benzothiazol-2-yl)-4-methylbenzenesulphonamide (PTS2ABT) was synthesized by the condensation of 2-aminobenzothiazole and 4- methylbenzenesulphonylchloride in acetone at 160 °C. The resulting crude precipitates were recrystallized in acetone/ethanol mix

ZnO and ZnO-nanoparticles: Efficient and reusable heterogeneous catalysts for one-pot synthesis of N-acylsulfonamides and sulfonate esters

Commercially available and preparative ZnO nanoparticles are reported as efficient and reusable catalysts for the chemoselective synthesis of N-acylsulfonamides and sulfonate esters. A one-pot sequential sulfonylation and acylation of amines took place to afford the N-acylsulfonamides in excellent yields under solvent-free conditions. The ZnO catalyst can be reused for without significant loss of catalytic activity.

Copper-mediated n-heteroarylation of primary sulfonamides: Synthesis of mono-n-heteroaryl sulfonamides

"Figure Presented" We describe the coupling of primary sulfonamides and various halogenated heterocyclic cores, with an emphasis on 2-heteroaryl halides, via copper catalysis. These studies enabled the synthesis of many new mono-N-heteroaryl sulfonamides.

Genotoxic potential of N-(benzothiazolyl)sulfonamide copper(II) complexes on yeast cells transformed with YEGFP expression constructs containing the RAD54 or RNR2 promoter

Four ternary complexes [Cu(L)2(phen)] where L is an N-(benzothiazol-2-yl)sulfonamide derivative have been prepared and their ability to cleave DNA has been studied. The complexes were structurally characterized with the aid of single-crystal X-ray crystallography. Whereas the molecular structure of the [Cu(L1)2(phen)] (1) [HL1 = N-(6-chlorobenzothiazol- 2-yl)benzenesulfonamide] and [Cu(L3)2(phen)] (3) [HL3 = N-(benzothiazol-2-yl)benzenesulfonamide] complexes can best be described as having a distorted square-planar geometry, that of the [Cu(L4) 2(phen)] (4) [HL4 = N-(benzothiazol-2-yl)toluenesulfonamide] complex shows a strictly square-planar geometry. The [Cu(L2)2(phen)MeOH] (2) [HL2 = N-(6-chlorobenzothiazol-2-yl)toluenesulfonamide] complex displays an axially elongated square-pyramidal coordination geometry in which the phen ligand binds at the basal plane. Viscosity and fluorescence measurements indicated that [Cu(L4)2(phen)] (4) has a propensity for binding calf thymus DNA. The four complexes were found to be efficient chemical nucleases, with ascorbate/H2O2 activation giving rise to hydroxyl and superoxide radicals as active cleaving species. The nuclease activity of 4 is not only the highest of the four complexes, but also much higher than that of the copper-phenanthroline complex. The ability of the complexes to cleave DNA within cells has been tested by monitoring the expression of the yEGFP gene containing reporter plasmid. The significant induction of fluorescence by complex 4 indicates that it is able to cleave DNA inside the cell. Wiley-VCH Verlag GmbH & Co. KGaA, 2006.