191981-04-1Relevant academic research and scientific papers
Solkane 365mfc is an environmentally benign alternative solvent for trifluoromethylation reactions
Kusuda, Akihiro,Kawai, Hiroyuki,Nakamura, Shuichi,Shibata, Norio
supporting information; experimental part, p. 1733 - 1735 (2011/03/19)
Solkane 365mfc is introduced for the first time as a new, environmentally benign alternative solvent for nucleophilic trifluoromethylation reactions. The Royal Society of Chemistry 2009.
Reaction of (Trifluoromethyl)trimethylsilane with Oxazolidin-5-ones: Synthesis of Peptidic and Nonpeptidic Trifluoromethyl Ketones
Walter, Magnus W.,Adlington, Robert M.,Baldwin, Jack E.,Schofield, Christopher J.
, p. 5179 - 5192 (2007/10/03)
(Trifluoromethyl)trimethylsilane (TMS-CF3, the Ruppert Reagent) reacts with a variety of amino acid derived N-substituted oxazolidin-5-ones in excellent yields. Mild acid hydrolysis of adducts with electron-releasing substituents at C-2 affords
Reaction of ruppert's reagent (TMS-CF3) with Oxazolidinones: Synthesis of protected α-amino trifluoromethylketones
Walter, Magnus W.,Adlington, Robert M.,Baldwin, Jack E.,Chuhan, John,Schofield, Christopher J.
, p. 7761 - 7764 (2007/10/02)
(Trifluoromethyl)trimethylsilane adds to α-amino acid derived oxazolidin-5-ones in excellent yields. The adducts can be converted into protected α-amino trifluoromethylketones by acid hydrolysis.
