191984-82-4

Upstream product

• 121-88-0 5-Nitro-2-aminophenol 
• 619-10-3 5-nitro-2-chlorophenol 
• 870-63-3 prenyl bromide 

Downstream Products

• 191984-84-6 4-chloro-3-(3-methyl-2-butenyloxy)-benzenamine 
• 856676-69-2 Benzoic acid (2S,5R)-5-{5-[3-(6-{3-[4-chloro-3-(3-methyl-but-2-enyloxy)-phenylcarbamoyl]-furan-2-yl}-hexyloxy)-prop-1-ynyl]-2,4-dioxo-3,4-dihydro-2H-pyrimidin-1-yl}-2,5-dihydro-furan-2-ylmethyl ester 
• 856676-66-9 2-(6-prop-2-ynyloxy-hexyl)-furan-3-carboxylic acid [4-chloro-3-(3-methyl-but-2-enyloxy)-phenyl]-amide 

Relevant academic research and scientific papers

New methodology for 2-alkylation of 3-furoic acids: Application to the synthesis of tethered UC-781/d4T bifunctional HIV reverse-transcriptase inhibitors

New methodology for 2-alkylation of 3-furoic acids is presented involving Wittig reactions of the 3-methoxycarbonyl-2-furanylmethylphosphonium salt. The methodology has been used to prepare a tethered 2-alkylated-UC-781/d4T conjugate as a potentially new type of HIV reverse-transcriptase inhibitor.

USE OF THIOCARBOXANILIDE DERIVATIVES FOR THE PREPARATION OF A MEDICAMENT FOR PREVENTING THE TRANSMISSION OF HIV TO UNINFECTED CELLS AND CONTRACEPTIVE COMPOSITIONS COMPRISING THE SAID DERIVATIVES

Method for preventing or inhibiting the transmission of HIV to susceptible uninfected cells by administering to the HIV, to cells infected with HIV, and/or to the uninfected cells, an effective amount of a compound of formula (I), wherein X is O or S, prior to the HIV or the cells infected with HIV, contacting the uninfected cells.

Compounds useful for the inhibition of the replication of HIV-1 and HIV-1 mutants

Compounds of the formula STR1 wherein X is O or S, useful for the inhibition of the replication of HIV-1 and reverse transcriptase mutants thereof, in vitro and in vivo.