191997-22-5Relevant academic research and scientific papers
K2S2O8mediated synthesis of 5-Aryldipyrromethanes and meso-substituted A4-Tetraarylporphyrins
Laha, Joydev K.,Hunjan, Mandeep Kaur
, p. 664 - 673 (2021/06/03)
The synthesis of dipyrromethanes from pyrrole and arylglyoxylic acids in the presence of K2S2O8at 90 C is reported affording dipyrromethanes in very good yields. Unlike an excess pyrrole traditionally used in dipyrromethane synthesis, the current method uses a stoichiometric amount of pyrrole avoiding any use of Br?nsted or Lewis acid. A gram scale synthesis of 5-phenyldipyrromethane is also achieved demonstrating potential scale up of dipyrromethanes using this method feasible. Subsequently, dipyrromethanes were converted to A4tetraarylporphyrins also in the presence of K2S2O8at 90C. A direct synthesis of A4-tetraphenylporphyrin from excess pyrrole and phenylglyoxylic acid in the presence of K2S2O8 at 90C is also reported.
Synthesis of 5,15-diarylporphyrins via orthoesters condensation with aryldipyrromethanes
Abada, Zahra,Ferrié, Laurent,Akagah, Bernardin,Lormier, Anh Tuan,Figadre, Bruno
scheme or table, p. 3175 - 3178 (2011/06/28)
General access to 5,15-diarylporphyrins in two steps is described. Generalization of this approach to tetra-substituted porphyrins allows the reproducible preparation of compounds, in some cases with high yields for porphyrins, which can be used in photodynamic therapy (PDT) in cancer today.
Synthetic porphyrins bearing β-propionate chains as photosensitizers for photodynamic therapy
Pereira, Nelson,Serra, Arménio C.,Pineiro, Marta,Gonsalves, António M. D'A. Rocha,Abrantes, Margarida,Laranjo, Mafalda,Botelho, Filomena
experimental part, p. 438 - 445 (2010/12/18)
Porphyrins with different numbers of β-propionate chains mimicking natural porphyrins were prepared via the 2+2 MacDonald type approach. Photodynamic activity against WiDr colon adenocarcinoma cells showed that activity is related to the number of β-propi
Fast and eco-friendly synthesis of dipyrromethanes by H2SO4 SiO2 catalysis under solvent-free conditions
Zhang, Yan,Liang, Jun,Shang, Zhicai
experimental part, p. 259 - 262 (2010/10/21)
For the first time, sillica-supported sulfuric acid has been used as a heterogeneous, reusable and efficient catalystat room temperature to give the corresponding dipyrromethanes in a very short reaction time. The new reactionprocedure is simple and solvent is not required.
Improved synthesis of meso substituted 21-Oxa and 2l-Thia tetra phenyl porphyrins
Srinivasan, Alagar,Sridevi, Bashyam,Reddy, Mereddy Venkat Ram,Narayanan, Seenichamy Jeyaprakash,Chandrashekar, Tavarekere K.
, p. 4149 - 4152 (2007/10/03)
An efficient method for the exclusive formation of 21-Oxa and 21-Thia tetra phenyl porphyrins in high yields by condensation of dipyrromethane and furan or thiophene diols is described.
