192122-41-1

Upstream product

• 192068-51-2 Methanesulfonic acid (1R,2S,3S,4S,5R,6S)-2,3,4,5,6-pentahydroxy-cyclohexyl ester 
• 642-38-6 quebrachitol 
• 192068-52-3 Methanesulfonic acid (3aS,4R,4aS,7aR,8S,8aS)-8-benzyloxy-2,2,6,6-tetramethyl-hexahydro-benzo[1,2-d;4,5-d']bis[1,3]dioxol-4-yl ester 
• 134182-86-8 Methanesulfonic acid (3aS,4S,5S,5aS,8aR,8bS)-5-methoxy-2,2,7,7-tetramethyl-hexahydro-benzo[1,2-d;3,4-d']bis[1,3]dioxol-4-yl ester 
• 58769-23-6 1L-3,4,:5,6-di-O-isopropylidene-2-O-methyl-chiro-inositol 
• 156672-21-8 Methanesulfonic acid (3aS,4R,4aS,7aR,8S,8aS)-8-hydroxy-2,2,6,6-tetramethyl-hexahydro-benzo[1,2-d;4,5-d']bis[1,3]dioxol-4-yl ester 
• 156672-20-7 Methanesulfonic acid (3aS,4S,5S,5aS,8aR,8bS)-5-hydroxy-2,2,7,7-tetramethyl-hexahydro-benzo[1,2-d;3,4-d']bis[1,3]dioxol-4-yl ester 

Downstream Products

• 1053256-80-6 (1S,2S,3R,4S,5S,6R)-3-Benzyloxy-5-benzyloxymethoxy-6-(4-methoxy-benzyloxy)-cyclohexane-1,2,4-triol 
• 1053697-81-6 C₃₈H₃₈O₉ 
• 1053254-94-6 C₄₂H₃₈O₁₀ 
• 156768-17-1 (3aR,4S,4aR,7aR,8S,8aS)-8-Benzyloxy-2,2,6,6-tetramethyl-hexahydro-benzo[1,2-d;4,5-d']bis[1,3]dioxol-4-ol 
• 148888-39-5 1D-6-O-benzyl-1,2:4,5-di-O-isopropylidene-3-deoxy-myo-inositol 
• 192122-45-5 C₄₁H₃₄O₁₀ 
• 192068-54-5 C₃₇H₃₄O₉ 
• 192122-43-3 C₃₄H₃₀O₉ 
• 290812-50-9 1L-1,3,4,5-O-benzyl-6-deoxy-6-(benzyloxymethyl)-chiro-inositol 2-[benzyl (R)-2-O-methyl-3-O-octadecyl phosphate] 
• 290812-51-0 1D-2,4,5,6-O-benzyl-3-deoxy-3-(benzyloxymethyl)-myo-inositol 2-[benzyl (R)-2-O-methyl-3-O-octadecyl phosphate] 
• 290812-52-1 1L-1,3,4,5-O-benzyl-6-deoxy-6-(benzyloxymethyl)-chiro-inositol 2-[benzyl (R)-2-O-methyl-3-O-octadecylcarbonate] 
• 290812-53-2 1D-2,4,5,6-O-benzyl-3-deoxy-3-(benzyloxymethyl)-myo-inositol 2-[benzyl (R)-2-O-methyl-3-O-octadecylcarbonate] 

Relevant academic research and scientific papers

Tools for cell signaling: Synthesis of the 3-phosphatase-resistant 1,3,4,5-Ins-P4 mimic, 1D-myo-inositol 1,4,5-trisphosphate 3-phosphorothioate

The synthesis of 1D-myo-inositol 1,4,5-trisphosphate 3-phosphorothioate, a 3-phosphatase-resistant analogue of 1,3,4,5-InsP4 is reported, and this compound is shown to elicit 45Ca2+ release with an EC50 which is

AKT INHIBITORS, PHARMACEUTICAL COMPOSITIONS, AND USES THEREOF

Disclosed are inhibitors of the serine/threonine kinase Akt, pharmaceutical compositions comprising such inhibitors, and a method of preventing or treating a disease or condition in an animal by the use of such inhibitors. The Akt inhibitors have the form

1D-myo-inositol 1,4,5-triphosphate and 1D-myo-inositol 1,3,4,5-tetrakisphosphate analogues modified at C-3; Synthesis of 1D-3-C-(Trifluoromethyl)-myo-inositol 1,4,5-triphosphate and 1L-chiro-inositol 1,2,3,5-tetrakisphosphate from L-quebrachitol

The novel 3-modified 1D-myo-inositol 1,4,5-trisphosphate [Ins(1,4,5)P3] analogues 1D-3-C-(trifluoromethyl)-myoinositol 1,4,5-trisphosphate and 1L-chiro-inositol 1,2,3,5-tetrakisphosphate are synthesized from L-quebrachitol, and the preliminary