192123-40-3

Usage

Uses

Used in Pharmaceutical Industry:
Tert-butyl 5-(Methoxy(Methyl)aMino)-5-oxopentanoate serves as a key intermediate in the synthesis of various pharmaceuticals. Its unique structure allows for the development of new drugs with specific therapeutic properties, contributing to advancements in medicinal chemistry.
Used in Agrochemical Industry:
In the agrochemical sector, tert-butyl 5-(Methoxy(Methyl)aMino)-5-oxopentanoate is utilized as an intermediate for the production of agrochemicals, including pesticides and herbicides. Its incorporation aids in the creation of more effective and targeted agricultural products.
Used in Organic Chemistry Research:
tert-butyl 5-(Methoxy(Methyl)aMino)-5-oxopentanoate is also employed as a valuable research tool in organic chemistry. Its reactivity and functional groups make it suitable for exploring new reaction pathways and understanding the mechanisms of complex organic transformations.
Used as a Reagent in Chemical Reactions:
Tert-butyl 5-(Methoxy(Methyl)aMino)-5-oxopentanoate functions as a reagent in a variety of chemical reactions, facilitating the synthesis of diverse organic compounds. Its presence can enhance reaction yields and selectivity, making it an indispensable component in many chemical processes.

Upstream product

• 63128-51-8 5-(tert-butoxy)-5-oxopentanoic acid 
• 6638-79-5 N,O-dimethylhydroxylamine*hydrochloride 
• 108-55-4 glutaric anhydride, 

Downstream Products

• 941292-97-3 (S)-β-tert-butoxycarboxyethyl-γ-(S)-N-benzyl-α-methylbenzyl amino-propylalcohol 

Relevant academic research and scientific papers

Practical synthesis of enantiomerically pure β2-amino acids via proline-catalyzed diastereoselective aminomethylation of aldehydes

Proline-catalyzed diastereoselective aminomethylation of aldehydes using a chiral iminium ion, generated from a readily prepared precursor, provides α-substituted-β-amino aldehydes with 85:15 to 90: 10 dr. The α-substituted-β-amino aldehydes can be reduce

CONCISE BETA2-AMINO ACID SYNTHESIS VIA ORGANOCATALYTIC AMINOMETHYLATION

The present invention provides a method for the synthesis of ?2-amino acids. The method also provides methods yielding a-substituted ?-amino aldehydes and ?-substituted γ-amino alcohols. The present method according to this invention allows for increased yield and easier purification using minimal chromatography or crystallization. The methods described herein are based on an aldehyde aminomethylation which involves a Mannich reaction between an aldehyde and a formaldehyde-derived N,O-acetal (iminium precursor) and a catalyst, such as, for example, L-proline or a pyrrolidine. The invention allows for large scale, commercial preparation of ?2-amino acids.

Building units for N-backbone cyclic peptides. Part 4. Synthesis of protected Nα-functionalized alkyl amino acids by reductive alkylation of natural amino acids

A new method for the synthesis of protected Nα-(ω-Y-alkyl) amino acids (Y is a thio, amino or carboxy group) and related compounds by reductive alkylation of natural amino acids is reported. These new amino acids serve as building units for the synthesis of backbone-cyclic peptides. They are orthogonally protected at the α-amino position by butoxycarbonyl (Boc) or 9-fluorenylmethoxycarbonyl (Fmoc), using trimethylsilyl temporary protection, to allow for their incorporation into peptides by solid phase peptide synthesis.