192130-86-2Relevant academic research and scientific papers
2,5-diketopiperazines, new chiral auxiliaries for asymmetric Diels-Alder reactions
Le, Thuy X.H.,Bussolari, Jacqueline C.,Murray, William V.
, p. 3849 - 3852 (2007/10/03)
Diketopiperazines have been utilized as chiral auxiliaries for asymmetric Diels-Alder reactions. Cyclo-S-phenylalanyl-R-proline (2) was found to be the most promising of these auxiliaries and afforded Diels-Alder adducts in high chemical yield (78-95%), with endo selectivities generally greater than 9:1. The diastereoselectivities observed were comparable to the best previously published values.
