19216-97-8

Upstream product

• 534-07-6 1,3-Dichloroacetone 
• 100-53-8 phenylmethanethiol 
• 816-39-7 1,3-dibromoroacetone 

Downstream Products

• 858835-58-2 1,3-bis-phenylmethanesulfonyl-acetone 
• 121664-59-3 1-Methyl-2-<1,3-bis(benzylthio)-2-oxopropylidene>pyrrolidine 
• 122012-99-1 2,4-Bis(benzylthio)-1-dimethylamino-3-oxo-1-butene 
• 122538-52-7 1,3-bis(benzylthio)acetone dimethylhydrazone 
• 122538-53-8 N'-<2-benzylthio-1-(benzylthiomethyl)ethyl>-N,N-dimethylhydrazine 
• 122538-54-9 N-<2-benzylthio-1-(benzylthiomethyl)ethyl>-N,N',N'-trimethylhydrazine 
• 4403-73-0 benzylsulfinic acid 
• 121664-61-7 1-Methyl-2-<1,3-bis(benzylthio)-2-hydroxypropyl>pyrrolidine 
• 122012-79-7 N,N-Dimethyl-2,4-bis(benzylthio)-3-hydroxybutylamine 
• 91187-66-5 N-<1,3-di(benzylthio)-2-propyl>-3-indolylcarbonylacetamide 
• 91187-65-4 N-<1,3-di(benzylthio)-2-propyl>-3-indolylacetamide 
• 91187-64-3 N-<1,3-di(benzylthio)-2-propyl>-4-toluenesulfonamide 
• 91187-63-2 N-<1,3-di(benzylthio)-2-propyl>benzamide 
• 47094-86-0 1,3-di(benzylthio)-2-propylamine 

Relevant academic research and scientific papers

Cyclic Ketones via the Reaction of Dithiols with 1,3-Dichloroacetone. An Unexpected Base-Catalyzed Rearrangement of α,α'-Dithia Ketones

The reaction of dithiols with 1,3-dichloroacetone under high dilution and catalyzed by cesium carbonate in DMF affords macrocyclic ketones in good yield.Examples of functionalized cyclophanes prepared in this way include 10, 15, 16, 19, 21, and 24.With Na

Potent dual EGFR/Her4 tyrosine kinase inhibitors containing novel (1,2-dithiolan-4-yl)acetamides

Modifications at C6 and C7 positions of 3-cyanoquinolines 6 and 7 led to potent inhibitors of the ErbB family of kinases particularly against EGFRWT and Her4 enzymes in the radioisotope filter binding assay. The lead (4, S

1,2-DITHIOLANE AND DITHIOL COMPOUNDS USEFUL IN TREATING MUTANT EGFR-MEDIATED DISEASES AND CONDITIONS

Compositions of the invention comprise 1,2-dithiolane, dithiol and related compounds useful as therapeutic agents for the treatment and prevention of diseases and conditions associated with aberrant EGFR activity.

1,2-DITHIOLANE AND DITHIOL COMPOUNDS USEFUL IN TREATING MUTANT EGFR-MEDIATED DISEASES AND CONDITIONS

Compositions of the invention comprise 1,2-dithiolane, dithiol and related compounds useful as therapeutic agents for the treatment and prevention of diseases and conditions associated with aberrant EGFR activity.

SYNTHESIS AND PROPERTIES OF N-SUBSTITUTED 4-AMINO-1,2-DITHIOLANES AND RELATED COMPOUNDS

Various methods for the synthesis of 4-acylamino-1,2-dithiolanes through N-substituted 1,3-di(benzylthio)-2-propylamines, which exhibit appreciable nematocidal activity, were studied.The 4-methylamino- and 4-amino-1,2-dithiolanes are extremely unstable.On the basis of a study of the electronic absorption spectra it was suggested that these compounds may undergo polymerization to linear polydisulfides at elevated temperatures.