192189-10-9

Usage

Uses

Used in Organic Chemistry:
3-IODO-5-METHOXYINDOLE-1-CARBOXYLIC ACID TERT-BUTYL ESTER is used as a building block in the synthesis of various pharmaceuticals, agrochemicals, and other organic compounds due to its unique properties and reactivity.
Used in Pharmaceutical Industry:
3-IODO-5-METHOXYINDOLE-1-CARBOXYLIC ACID TERT-BUTYL ESTER is used as an intermediate in the development of new pharmaceutical compounds, leveraging its versatility and functionality to create novel drug candidates.
Used in Agrochemical Industry:
3-IODO-5-METHOXYINDOLE-1-CARBOXYLIC ACID TERT-BUTYL ESTER is used as a key component in the synthesis of agrochemicals, contributing to the development of innovative and effective products for agricultural applications.

InChI:InChI=1/C14H16INO3/c1-14(2,3)19-13(17)16-8-11(15)10-7-9(18-4)5-6-12(10)16/h5-8H,1-4H3

Upstream product

• 1006-94-6 5-methoxylindole 
• 24424-99-5 di-tert-butyl dicarbonate 
• 85092-86-0 3-iodo-5-methoxy-1H-indole 

Downstream Products

• 1239950-39-0 3-(1-hydroxypentyl)-5-methoxyindole-1-carboxylic acid tert-butyl ester 
• 99275-47-5 1-(tert-butyloxycarbonyl)-5-methoxyindole 
• 1239950-38-9 3-(hydroxyphenylmethyl)-5-methoxyindole-1-carboxylic acid tert-butyl ester 
• 1239950-40-3 3-(1-hydroxyethyl)-5-methoxyindole-1-carboxylic acid tert-butyl ester 
• 86138-19-4 (+)-5-Methoxy-a-methyltryptamine 
• 1256359-99-5 tert-butyl 5-methoxy-3-(4,4,5,5-tetramethyl-1,3,2-dioxaborolan-2-yl)-indole-1-carboxylate 
• 348639-01-0 2-(5-methoxy-1-methyl-1H-indol-3-yl)-1-(toluene-4-sulfonyl)-1H-pyrrolo[2,3-b]pyridine 
• 348640-18-6 2-(5-methoxy-1H-indol-3-yl)-1-(toluene-4-sulfonyl)-1H-pyrrolo[2,3-b]pyridine 
• 348640-19-7 C₁₄H₁₈BNO₅ 
• 1048039-41-3 tert-butyl 3-(((2S,3R)-2-(benzyloxycarbonyl)-1-((S)-1-phenylethyl)pyrrolidin-3-yl)methyl)-5-methoxy-1H-indole-1-carboxylate 

Relevant academic research and scientific papers

COMPOUNDS AND METHOD OF USE

This present disclosure relates to compounds with ferroptosis inducing activity, a method of treating a subject with cancer with the compounds, and combination treatments with a second therapeutic agent.

One-pot synthesis of camalexins and 3,3′-biindoles by the Masuda borylation-Suzuki arylation (MBSA) sequence

The Masuda borylation/Suzuki arylation (MBSA) sequence starting from N-protected 3-iodoindoles has successfully been extended to the coupling of five-membered heterocycles and indoles in the arylation step, which could not be achieved with previously developed MBSA methods. By this approach the one-pot nature of the method as well as the use of a simple catalyst system has been retained. The applicability of the method has been demonstrated by the facile synthesis of camalexins and 3,3′-biindoles, compounds of special interest due to their pronounced antifungal, antimicrobial and cytotoxic activities. The Masuda borylation/Suzuki arylation sequence furnishes in a concise one-pot manner camalexins and 3,3′-biindoles, compounds that show pronounced antifungal, antimicrobial, and cytotoxic activities. Copyright

One-pot synthesis of diazine-bridged bisindoles and concise synthesis of the marine alkaloid hyrtinadine A

Diazine-bridged bisindoles are readily obtained from N-Bocprotected 3-iodoindoles and 3-iodo-7-azaindole in a pseudo three-component reaction involving a one-pot Masuda borylation-Suzuki arylation sequence. Some of the title com-pounds display promising c

Design of potent IGF1-R inhibitors related to bis-azaindoles

From an azaindole lead, identified in high throughput screen, a series of potent bis-azaindole inhibitors of IGF1-R have been synthesized using rational drug design and SAR based on a in silico binding mode hypothesis. Although the resulting compounds produced the expected improved potency, the model was not validated by the co-crystallization experiments with IGF1-R.

Amino-zinc-ene-enolate cyclization: A short access to cis-3-substituted prolino-homotryptophane derivatives

(Chemical Equation Presented) Proline chimeras are useful tools for medicinal chemistry and/or biological applications. The asymmetric synthesis of cis-3-substituted prolines can be easily achieved via amino-zinc-ene-enolate cyclization followed by transm

Hydroboration and Suzuki-Miyaura coupling reactions with the electronically modulated variant of an ynamine: The synthesis of (E)-β-arylenamides

The first hydroboration of an 1-alkynylamide - the electronically modulated variant of an ynamine - is described. This hydroboration in combination with a Suzuki-Miyaura cross-coupling reaction with aryl bromides or aryl iodides allows a flexible synthesis of (E)-β-arylenamides and 3-(2'-amidovinyl)indoles with high degree of molecular diversity. (C) 2000 Elsevier Science Ltd.

Novel non-nucleoside inhibitors of human immunodeficiency virus type 1 reverse transcriptase. 6. 2-Indol-3-yl- and 2-azaindol-3-yl- dipyridodiazepinones

Modification of the non-nucleoside inhibitor of HIV-1 reverse transcriptase nevirapine (Viramune) by incorporation of a 2-indolyl substituent confers activity against several mutant forms of the enzyme.