1256359-99-5

Usage

Uses

Used in Pharmaceutical Industry:
1-Boc-5-Methoxyindole-3-boronic acid, pinacol ester is used as a building block for the synthesis of various pharmaceuticals, leveraging its reactivity in organic synthesis to create complex organic molecules with potential therapeutic applications.
Used in Organic Synthesis:
In the realm of organic synthesis, 1-Boc-5-Methoxyindole-3-boronic acid, pinacol ester is used as a key intermediate for the construction of diverse organic molecules, taking advantage of its boronic acid ester properties to facilitate the formation of carbon-carbon bonds through Suzuki coupling reactions.
Used in Chemical Research:
1-Boc-5-Methoxyindole-3-boronic acid, pinacol ester is employed as a research tool in chemical laboratories, where its unique properties are explored for understanding reaction mechanisms and developing new synthetic methodologies.

Upstream product

• 1006-94-6 5-methoxylindole 
• 85092-86-0 3-iodo-5-methoxy-1H-indole 
• 192189-10-9 3-iodo-5-methoxyindole-1-carboxylic acid tert-butyl ester 
• 25015-63-8 4,4,5,5-tetramethyl-[1,3,2]-dioxaboralane 
• 99275-47-5 1-(tert-butyloxycarbonyl)-5-methoxyindole 
• 73183-34-3 bis(pinacol)diborane 
• 348640-11-9 tert-butyl 3-bromo-5-methoxy-1H-indole-1-carboxylate 

Downstream Products

• 1310704-53-0 tert-butyl 5-methoxy-3-(1-methyl-6-tosyl-1,6-dihydropyrazolo[3,4-d]pyrrolo[2,3-b]pyridin-7-yl)-1H-indole-1-carboxylate 
• 1350378-16-3 tert-butyl 3-(5-fluoro-4-(2-(1-hydroxycyclobutyl)thiazol-5-yl)-1-tosyl-1H-pyrrolo[2,3-b]pyridin-2-yl)-5-methoxy-1H-indole-1-carboxylate 

Relevant academic research and scientific papers

Synthesis of scalaridine A

A synthesis of the pyridine-linked bisindole alkaloid scalaridine A is described. An iridium catalyzed, directed C-H borylation of N-Boc-5-methoxyindole gave the corresponding 3-borylindole, which underwent a one-pot, double Suzuki-Miyaura cross-coupling reaction with 3,5-dibromopyridine to install the entire heteroaromatic framework of the natural product. Removal of the protecting groups gave a synthetic sample of scalaridine A, which was spectroscopically identical to that described in the isolation report.

Five-membered heterocyclic oxo carboxylic acid compound and medical application thereof

The invention relates to a five-membered heterocyclic oxo carboxylic acid compound and a medical application thereof. Specifically, the invention relates to a compound, a pharmaceutical salt, a prodrug, a hydrate, a solvate or a crystal form as shown in a formula (I), and also relates to a preparation method of the compound, a pharmaceutical composition containing the compound and an application of the pharmaceutical composition as a secretion regulator of interferon type I, especially as an STING agonist in preparation of medicines for preventing and/or treating I-type interferon related diseases.

Hyrtinadine alkaloid derivative as well as preparation and application of Hyrtinadine alkaloid derivative in resisting plant viruses and germs

The invention relates to a Hyrtinadine alkaloid derivative as well as preparation and application of the Hyrtinadine alkaloid derivative in resisting plant viruses and germs. The Hyrtinadine alkaloidderivative shows especially excellent plant virus resist

One-pot synthesis of camalexins and 3,3′-biindoles by the Masuda borylation-Suzuki arylation (MBSA) sequence

The Masuda borylation/Suzuki arylation (MBSA) sequence starting from N-protected 3-iodoindoles has successfully been extended to the coupling of five-membered heterocycles and indoles in the arylation step, which could not be achieved with previously developed MBSA methods. By this approach the one-pot nature of the method as well as the use of a simple catalyst system has been retained. The applicability of the method has been demonstrated by the facile synthesis of camalexins and 3,3′-biindoles, compounds of special interest due to their pronounced antifungal, antimicrobial and cytotoxic activities. The Masuda borylation/Suzuki arylation sequence furnishes in a concise one-pot manner camalexins and 3,3′-biindoles, compounds that show pronounced antifungal, antimicrobial, and cytotoxic activities. Copyright

PYRROLOPYRIDINE AND PYRROLOPYRIMIDINE INHIBITORS OF KINASES

The present invention relates to compounds of formula (I) or pharmaceutical acceptable salts, wherein A, B, R1, R2, R3, R4a, R5, and Z are defined in the description. The present invention relates also to methods of making said compounds, and compositions containing said compounds which are useful for inhibiting kinases such as aurora.

One-pot synthesis of diazine-bridged bisindoles and concise synthesis of the marine alkaloid hyrtinadine A

Diazine-bridged bisindoles are readily obtained from N-Bocprotected 3-iodoindoles and 3-iodo-7-azaindole in a pseudo three-component reaction involving a one-pot Masuda borylation-Suzuki arylation sequence. Some of the title com-pounds display promising c