19229-59-5

Upstream product

• 67-56-1 methanol 
• 2862-03-5 N-acetyl-O¹-benzyl-O⁴,O⁶-(R)-benzylidene-β-muramic acid 
• 122089-21-8 benzyl 2-acetamido-2-deoxy-4,6-O-isopropilidene-3-O--β-D-glucopyranoside 

Downstream Products

• 121999-75-5 benzyl 2-acetamido-2-deoxy-6-O-diphenylphosphono-3-O--β-D-glucopyranoside 
• 121999-76-6 benzyl 2-acetamido-2-deoxy-6-O-diphenylphosphono-3-O--4-O-(tetrahydropyran-2-yl)-β-D-glucopyranoside 
• 121999-77-7 benzyl 2-acetamido-3-O-(D-1-carboxyethyl)-2-deoxy-6-O-diphenylphosphono-4-O-(tetrahydropyran-2-yl)-β-D-glucopyranoside 
• 78569-15-0 benzyl 2-acetamido-4,6-dichloro-2,4,6-trideoxy-3-O-(D-2-propionyl-L-alanyl-D-isoglutamine benzyl ester)-α-D-galactopyranoside 
• 78569-12-7 benzyl 2-acetamido-2,4,6-trideoxy-3-O-(D-2-propionyl-L-alanyl-D-isoglutamine benzyl ester)-α-D-xylo-hexopyranoside 
• 40269-15-6 benzyl 2-acetamido-2,4,6-trideoxy-3-O--α-D-xylo-hexopyranoside 
• 40269-14-5 benzyl 2-acetamido-4,6-dichloro-2,4,6-trideoxy-3-O--α-D-galactopyranoside 

Relevant academic research and scientific papers

Synthesis of biologically active biotinylated muramyl dipeptides

Muramyl dipeptide (MDP) is believed to interact with an innate immune receptor, Nod2. To identify the cellular receptor for MDP, we have synthesized biotinylated MDP isomers and tested the ability of these compounds to activate Nod2 in a cell-based assay. We found that the modification of MDP does not perturb its ability to activate Nod2. These tagged versions of MDP will be useful to identify the cellular receptor of the immunostimulatory molecules.

Synthesis and Immunoadjuvant Activity of N-Acetyl-6-O-phosphono-muramoyl-L-alanyl-D-isoglutamine Methyl Ester and Its Lipophilic Derivatives

N-acetyl-6-O-phosphono-muramoyl-L-alanyl-D-isoglutamine methyl ester and a variety of its 1-α-O-acyl derivatives were synthesized from benzyl 2-acetamido-2-deoxy-3-O--β-D-glucopyranoside.Their immunoadjuvant activity in guinea-