192329-94-5

Basic information

• Product Name: 4-(2-Pyridyloxy)phenylsulphonyl chloride
• Synonyms: 4-(2-Pyridyloxy)phenylsulphonyl chloride
• CAS NO: 192329-94-5
• Molecular Formula: C11H9Cl2NO3S
• Molecular Weight: 306.17
• Mol File: 192329-94-5.mol
• Article Data: 5

Chemical Properties

• Boiling Point: 392.1°C at 760 mmHg
• Flash Point: 191°C
• Appearance: /
• Density: 1.42g/cm³
• Vapor Pressure: 5.29E-06mmHg at 25°C
• Refractive Index: 1.596
• Storage Temp.: Inert atmosphere,Room Temperature
• CAS DataBase Reference: 4-(2-Pyridyloxy)phenylsulphonyl chloride(CAS DataBase Reference)
• NIST Chemistry Reference: 4-(2-Pyridyloxy)phenylsulphonyl chloride(192329-94-5)
• EPA Substance Registry System: 4-(2-Pyridyloxy)phenylsulphonyl chloride(192329-94-5)

Safety Data

• Hazardous Substances Data: 192329-94-5(Hazardous Substances Data)

Usage

General Description

4-(2-Pyridyloxy)phenylsulphonyl chloride is a chemical compound with the molecular formula C12H9ClN2O3S. It is a sulfonyl chloride derivative of 4-(2-pyridyloxy)phenol, and is used in organic synthesis as a reagent for introducing the sulfonyl chloride functional group into organic molecules. 4-(2-Pyridyloxy)phenylsulphonyl chloride is a clear, colorless to light yellow liquid at room temperature, and is known for its strong and pungent odor. It is often used as a building block in the synthesis of pharmaceuticals, agrochemicals, and other fine chemicals. Additionally, it may also find utility in the field of materials science as a precursor for the synthesis of functional materials.

InChI:InChI=1/C11H8ClNO3S/c12-17(14,15)10-6-4-9(5-7-10)16-11-3-1-2-8-13-11/h1-8H

Upstream product

• 4783-68-0 2-phenoxypyridine 

Relevant articles and documents

COMPOUNDS WITH PGD2 ANTAGONIST ACTIVITY

Compounds of general formula (I); wherein R1, R2, R3 and R4 are independently hydrogen, halo, -C1-C6 alkyl, -O(C1-C6 alkyl), -C1-C6 alkyl(C3-C7 cycloalkyl), -CON(R9)2, -SOR9, -S02R9, -S02N(R9)2, -N(R9)2, -NR9OR9, -C02R9, COR9, -SR9, -OH, -N02 or -CN; each R9 independently hydrogen or C1-C6 alkyl, R5 and R6 are each independently hydrogen, or C1-C6 alkyl or together with the carbon atom to which they are attached form a C3-C7 cycloalkyl group; R7 is hydrogen or C1-C6 alkyl; R8 is C1-C6 alkyl, C2-C6 alkenyl, C2-C6 alkynyl or an aromatic moiety, any of which may optionally be substituted with one or more substituents selected from halo, -SOR13 -S02R13, -R14, -OR14, -CON(R14)2 -SOR14, -S02R14, -S02N(R14) -S02N(R14)2, -N(R 14)2, NR14COR14, -CO2R14, COR14, -SR14, -N02 or -CN; wherein R13 is a 5 to 7 membered heterocyclic ring, and each R14 is independently hydrogen, alkyl or aryl, the aryl being optionally substituted by -R9, -OR9, -CON(R9)2, -SOR9 -S02R9, -S02N(R9)2, -N(R9)2, NR9COR9, -C02R9, -COR9, -SR9, halo, -N02 or -CN, wherein R9 is as defined above; provided that when R1, R3 and R4 are hydrogen and R2 is hydrogen, halogen or -0(C1-C6)alkyl, R8 is not unsubstituted phenyl or phenyl substituted by halo, C1-C6 alkyl, -0(C1-C6)alkyl, -S(C1-C6)alkyl or -CO(C1-C6)alkyl, or pharmaceutically acceptable salts, hydrates, solvates, complexes or prodrugs therof are useful in the treatment of allergic diseases such as asthma, allergic rhinitis and atopic dermatitis

Metalloproteinase inhibitors, pharmaceutical compositions containing them, and their pharmaceutical uses

The present invention relates to compounds of formula I:wherein Ar is an aryl group or a heteroaryl group; X is -NH-OH or -OH; R1 is H, -CH(R3)(R4), -C(O)R3, a cycloalkyl group, a heterocycloalkyl group, an aryl group, or a heteroaryl group, wherein R3 is

METALLOPROTEINASE INHIBITORS, PHARMACEUTICAL COMPOSITIONS CONTAINING THEM AND THEIR PHARMACEUTICAL USES

Compounds of the formula I: STR1 wherein Y is O or S, Ar is an aryl group or a heteroaryl group, R is H, an alkyl group, a cycloalkyl group, a heterocycloalkyl group, an aryl group, a heteroaryl group, or--C(O)R. sub.1, wherein R 1 is hydrogen, an alkyl group, a cycloalkyl group, a heterocycloalkyl group, an aryl group, a heteroaryl group, or NR. sub.2 R 3, wherein R 2 and R 3 independently are hydrogen, an alkyl group, a cycloalkyl group, a heterocycloalkyl group, an aryl group, or a heteroaryl group, and X is--NH--OH or--OH. Pharmaceutically acceptable prodrugs, salts and solvates of these compounds. Methods of inhibiting the activity of metalloproteinases by administering a compound of the formula I or a prodrug, salt of solvate thereof. Pharmaceutical compositions comprising an effective amount of these compounds, prodrugs, salts, and solvates.