4783-68-0

Basic information

• Product Name: 2-PHENOXYPYRIDINE
• Synonyms: 2-PHENOXYPYRIDINE;PHENYL 2-PYRIDYL ETHER;2-Pyridylphenyl ether
• CAS NO: 4783-68-0
• Molecular Formula: C₁₁H₉NO
• Molecular Weight: 171.2
• EINECS: 225-328-3
• Product Categories: Heterocycle-Pyridine series
• Mol File: 4783-68-0.mol
• Article Data: 49

Chemical Properties

• Boiling Point: 274.4°Cat760mmHg
• Flash Point: 100.6°C
• Appearance: /
• Density: 1.117g/cm³
• Vapor Pressure: 0.00906mmHg at 25°C
• Refractive Index: 1.577
• Storage Temp.: Sealed in dry,Room Temperature
• PKA: 2.59±0.12(Predicted)
• CAS DataBase Reference: 2-PHENOXYPYRIDINE(CAS DataBase Reference)
• NIST Chemistry Reference: 2-PHENOXYPYRIDINE(4783-68-0)
• EPA Substance Registry System: 2-PHENOXYPYRIDINE(4783-68-0)

Safety Data

• Hazardous Substances Data: 4783-68-0(Hazardous Substances Data)

Usage

General Description

2-PhenoxyPyridine is a chemical compound with the molecular formula C11H9NO. It is a pale yellow liquid with a faint odor that is commonly used as an intermediate in the synthesis of pharmaceuticals, pesticides, and other organic compounds. 2-PhenoxyPyridine is also known for its use as a reagent in organic chemical reactions, such as the formation of carbon-nitrogen bonds in the production of heterocyclic compounds. It is considered to have low toxicity and is not known to have any significant harmful effects on human health or the environment when used in accordance with safe handling practices. However, prolonged or excessive exposure to 2-PhenoxyPyridine should be avoided to prevent any potential health risks.

InChI:InChI=1/C11H9NO/c1-2-6-10(7-3-1)13-11-8-4-5-9-12-11/h1-9H

Upstream product

• 109-04-6 2-bromo-pyridine 
• 139-02-6 sodium phenoxide 
• 108-95-2 phenol 
• 372-48-5 2-fluoropyridine 
• 142-08-5 2-Pyridone 
• 66715-65-9 pyridine-2-sulfonyl chloride 
• 2637-34-5 2-Sulfanylpyridine 
• 23628-24-2 2-chloro-6-phenoxypyridine 
• 16879-02-0 6-chloro-2-pyridone 
• 23353-96-0 pyridin-2(3H)-one 
• 26838-86-8 pyridine-2-carboxylic acid phenyl ester 
• 762-42-5 dimethyl acetylenedicarboxylate 
• 626-60-8 3-Chloropyridine 
• 5029-67-4 2-iodopyridine 

Downstream Products

• 192329-94-5 4-(pyridin-2-yloxy)-benzenesulfonyl chloride 
• 1173294-85-3 phenyl(2-(pyridin-2-yloxy)phenyl)methanone 
• 1357293-53-8 2-(2-fluorophenoxy)pyridine 
• 35974-37-9 2-(pyridin-2-yloxy)phenol 
• 28355-48-8 2-(3-nitrophenoxy)pyridine 
• 554-84-7 meta-nitrophenol 
• 68716-48-3 4,4,5,5-tetramethyl-2-(3-nitrophenyl)-1,3,2-dioxaborolane 
• 1173294-98-8 (4-bromophenyl)(5-methoxy-2-(pyridin-2-yloxy)phenyl)methanone 
• 1173294-97-7 (2-(pyridin-2-yloxy)phenyl)(p-tolyl)methanone 
• 1173294-99-9 (3,5-dichlorophenyl)(2-(pyridin-2-yloxy)phenyl)methanone 
• 220693-30-1 [AuCl₃(NC₅H₄(OC₆H₅))] 
• 142-08-5 2-Pyridone 
• 108-95-2 phenol 
• 32101-42-1 2-(2,4-dinitro-phenoxy)-pyridine 

Relevant articles and documents

A CONVENIENT METHOD FOR THE PREPARATION OF 6-PHENOXY-2-PYRIDINECARBALDEHYDE

6-Phenoxy-2-pyridinecarbaldehyde was prepared in good yields through a few reaction steps utilizing Grignard reaction which has been regarded disadvantageous for preparation of pyridinecarbaldehydes.

Remarkably Efficient Iridium Catalysts for Directed C(sp2)-H and C(sp3)-H Borylation of Diverse Classes of Substrates

Here we describe the discovery of a new class of C-H borylation catalysts and their use for regioselective C-H borylation of aromatic, heteroaromatic, and aliphatic systems. The new catalysts have Ir-C(thienyl) or Ir-C(furyl) anionic ligands instead of the diamine-type neutral chelating ligands used in the standard C-H borylation conditions. It is reported that the employment of these newly discovered catalysts show excellent reactivity and ortho-selectivity for diverse classes of aromatic substrates with high isolated yields. Moreover, the catalysts proved to be efficient for a wide number of aliphatic substrates for selective C(sp3)-H bond borylations. Heterocyclic molecules are selectively borylated using the inherently elevated reactivity of the C-H bonds. A number of late-stage C-H functionalization have been described using the same catalysts. Furthermore, we show that one of the catalysts could be used even in open air for the C(sp2)-H and C(sp3)-H borylations enabling the method more general. Preliminary mechanistic studies suggest that the active catalytic intermediate is the Ir(bis)boryl complex, and the attached ligand acts as bidentate ligand. Collectively, this study underlines the discovery of new class of C-H borylation catalysts that should find wide application in the context of C-H functionalization chemistry.

N - And O -arylation of pyridin-2-ones with diaryliodonium salts: Base-dependent orthogonal selectivity under metal-free conditions

Metal-free N- and O-arylation reactions of pyridin-2-ones as ambident nucleophiles have been achieved with diaryliodonium salts on the basis of base-dependent chemoselectivity. In the presence of N,N-diethylaniline in fluorobenzene, pyridin-2-ones were very selectively converted to N-arylated products in high yields. On the other hand, the O-arylation reactions smoothly proceeded with the use of quinoline in chlorobenzene, leading to high yields and selectivities. In these methods, a variety of pyridin-2-ones in addition to pyridin-4-one and a set of diaryliodonium salts were accepted as suitable reaction partners.

A directing group-assisted ruthenium-catalyzed approach to access: Meta -nitrated phenols

meta-Selective C-H nitration of phenol derivatives was developed using a Ru-catalyzed σ-activation strategy. Cu(NO3)2·3H2O was employed as the nitrating source, whereas Ru3(CO)12 was found to be the most suitable metal catalyst for the protocol. Mechanistic studies suggested involvement of an ortho-CAr-H metal intermediate, which promoted meta-electrophilic aromatic substitution and silver-assisted free-radical pathway.