192434-77-8Relevant academic research and scientific papers
(3-substituted benzyl)thiazolidine-2,4-diones as structurally new antihyperglycemic agents
Nomura, Masahiro,Kinoshita, Susumu,Satoh, Hiroya,Maeda, Toshio,Murakami, Koji,Tsunoda, Masaki,Miyachi, Hiroyuki,Awano, Katsuya
, p. 533 - 538 (2007/10/03)
A series of 3-[(2,4-dioxothiazolidin-5-yl)methyl]benzamide derivatives was prepared as part of a search for antidiabetic agents. A structure- activity relationship study of these compounds led to the identification of 5-[(2,4-dioxothiazolidin-5-yl)methyl]-2-methoxy-N-[[4- (trifluoromethyl)phenyl]methyl]benzamide (KRP-297) as a candidate drug for the treatment of diabetes mellitus.
N-substituted dioxothiazolidylbenzamide derivatives and process for producing the same
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, (2008/06/13)
The invention provides novel N-substituted dioxothiazolidylbenzamide derivatives that improve the insulin resistance and have potent hypoglycemic effect and lipid-lowering effect, and the process for preparing them, and relates to N-substituted dioxothiazolidylbenzamide derivatives characterized by being represented by a general formula (1) STR1 ?wherein R1 and R2 denote identically or differently hydrogen atoms, lower alkyl groups with carbon atoms of 1 to 4, lower alkoxy groups with carbon atoms of 1 to 3, lower haloalkyl groups with carbon atoms of 1 to 3, lower haloalkoxy groups with carbon atoms of 1 to 3, halogen atoms or hydroxyl groups, or R1 and R2 combine to form a methylenedioxy group, R3 denotes a hydrogen atom, lower alkoxys group with carbon atoms of 1 to 3, hydroxyl group or halogen atom, R4 denotes a hydrogen or lower alkyl group with carbon atoms of 1 to 3, n denotes an integer of 0 to 2, and X denotes N or CH!, and process for preparing the same.
