19244-35-0

Basic information

• Product Name: (4,5,6,7-TETRACHLORO-1,3-DIOXO-1,3-DIHYDRO-ISOINDOL-2-YL)-ACETIC ACID
• Synonyms: (4,5,6,7-TETRACHLORO-1,3-DIOXO-1,3-DIHYDRO-ISOINDOL-2-YL)-ACETIC ACID;4,5,6,7-Tetrachloro-1,3-dioxo-2-isoindolineacetic acid;2-(4,5,6,7-tetrachloro-1,3-dioxo-2,3-dihydro-1H-isoindol-2-yl)acetic acid
• CAS NO: 19244-35-0
• Molecular Formula: C10H3Cl4NO4
• Molecular Weight: 342.94712
• Mol File: 19244-35-0.mol
• Article Data: 5

Chemical Properties

• Melting Point: 306-308℃ (methanol )
• Appearance: /
• Density: 1.878±0.06 g/cm3 (20 ºC 760 Torr)
• CAS DataBase Reference: (4,5,6,7-TETRACHLORO-1,3-DIOXO-1,3-DIHYDRO-ISOINDOL-2-YL)-ACETIC ACID(CAS DataBase Reference)
• NIST Chemistry Reference: (4,5,6,7-TETRACHLORO-1,3-DIOXO-1,3-DIHYDRO-ISOINDOL-2-YL)-ACETIC ACID(19244-35-0)
• EPA Substance Registry System: (4,5,6,7-TETRACHLORO-1,3-DIOXO-1,3-DIHYDRO-ISOINDOL-2-YL)-ACETIC ACID(19244-35-0)

Safety Data

• Hazardous Substances Data: 19244-35-0(Hazardous Substances Data)

Usage

General Description

(4,5,6,7-Tetrachloro-1,3-dioxo-1,3-dihydro-isoindol-2-yl)-acetic acid is a synthetic compound with potential uses in the field of pharmaceuticals and agrochemicals. It belongs to the class of organic compounds known as phenylacetic acids, which are compounds containing a phenylacetic acid moiety, which consists of a phenyl group attached to an acetic acid. (4,5,6,7-TETRACHLORO-1,3-DIOXO-1,3-DIHYDRO-ISOINDOL-2-YL)-ACETIC ACID may have potential therapeutic properties, such as anti-inflammatory and analgesic effects, and it could also be used in the synthesis of other pharmaceutical compounds. However,

Upstream product

• 117-08-8 tetrachlorophthalic anhydride 
• 56-40-6 glycine 
• 362043-70-7 TCP-Gly-OBu-t 
• 857801-96-8 N,N-tetrachlorophthaloyl-glycine-nitrile 

Downstream Products

• 1446318-06-4 C₁₈H₁₂Cl₄N₂O₄ 
• 1446318-09-7 C₁₈H₁₄Cl₄N₂O₅ 

Relevant articles and documents

PIGMENT DISPERSION COMPRISING PHTHALIMIDE AND DERIVATIVE THEREOF, AND COLORING COMPOSITION

PROBLEM TO BE SOLVED: To provide a pigment dispersion that can inhibit a rise in the viscosity of a phthalocyanine pigment dispersion, and can also inhibit the deterioration of contrast in the coating of a coloring composition containing the pigment dispersion, and provide a coloring composition. SOLUTION: A pigment dispersion contains at least one selected from a phthalimide represented by formula (1) and a derivative thereof, a phthalocyanine pigment, a dispersant and a solvent (R1-R4 are H or a halogen atom; Q is (i) H, (ii) a C1-C4 alkyl group, optionally having a substituent X binding to a terminal carbon atom, or (iii) an aryl group, optionally having a substituent Y binding to a carbon atom of an aromatic ring, where the substituent X is an acetyl group, a carboxyl group, a phosphate group or a sulfone group; the substituent Y is a methyl group, an acetyl group, a carboxyl group, a phosphate group or a sulfone group). SELECTED DRAWING: None COPYRIGHT: (C)2018,JPOandINPIT

A facile and green synthesis of novel imide and amidic acid derivatives of phenacetin as potential analgesic and anti-pyretic agents

Facile and green syntheses of potential analgesic and antipyretic compounds, N-(4-ethoxy-phenyl)-2-(1,3- dioxo-1,3-dihydroisoindol-2-yl)acetamide derivatives 6a-g and N-[(4-ethoxy-phenylcarbamoyl)methyl]phthalamic acid derivatives 10a-g have been developed. Two synthetic routes (A and B) have been established for the preparation of 6a-g. In the route-A, 4-ethoxyaniline 2 was reacted with chloroacetyl chloride 3 in a solution of potassium acetate and acetic acid to yield N-(4-ethoxyphenyl)-2-chloroacetamide 4. The latter was reacted with imide compounds 5a-g either in triethanolamine as a green solvent or in solid phase in the presence of TEBAC and KI to yield 6a-g. Alternatively, in the route-B, reaction of anhydrides 7a-g with glycine 8 yielded the (1, 3-dioxo-1, 3-dihydroisoindol-2-yl)acetic acid derivatives 9a-g which on reaction with 2 either in triethnolamine and DCC as a dehydrating agent or in solid phase in the presence of DCC gave 6a-g. The latter were hydrolyzed in 0.5N ethanolic KOH to afford 10a-g.

Microwave-assisted rapid synthesis of α-amino-β-lactams

A rapid and convenient approach to α-amino-β-lactams has been developed using the tetrachlorophthalimido group as a masked amino substituent. Reaction between glycine and tetrachlorophthalic anhydride in DMF for about 90 sec in a domestic microwave oven led to an imidoacetic acid in high yield; the corresponding acid chloride reacted with Schiff bases to provide mixtures of trans and cis β-lactams. Nearly exclusive formation of trans β-lactams could be achieved in some cases in a few minutes by conducting β-lactam formation under strong microwave irradiation. Facile conversion to α-amino-β-lactams was realized in 5-10 minutes via solventless reaction of these α-amino-β-lactams with ethylenediamine at room temperature.