192440-35-0Relevant academic research and scientific papers
Palladium-catalyzed intermolecular aminoacetoxylation of alkenes and the influence of PhI(OAc)2 on aminopalladation stereoselectivity
Martinez, Claudio,Wu, Yichen,Weinstein, Adam B.,Stahl, Shannon S.,Liu, Guosheng,Muniz, Kilian
, p. 6309 - 6315 (2013/07/26)
A modified protocol has been identified for Pd-catalyzed intermolecular aminoacetoxylation of terminal and internal alkenes that enables the alkene to be used as the limiting reagent. The results prompt a reassessment of the stereochemical course of these reactions. X-ray crystallographic characterization of two of the products, together with isotopic labeling studies, show that the amidopalladation step switches from a cis-selective process under aerobic conditions to a trans-selective process in the presence of diacetoxyiodobenzene.
Enantio- and stereoselective syntheses of monodeuterium-labeled glycerols
Yagi,Oikawa,Ichihara
, p. 1038 - 1040 (2007/10/03)
An efficient method is described for synthesizing and four possible diastereomers of stereochemically defined monodeuterated glycerols by utilizing Sharpless asymmetric dihydroxylation.
