192449-15-3Relevant academic research and scientific papers
METHOD FOR SYNTHESIZING OPTICALLY ACTIVE CARBONYL COMPOUNDS
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Paragraph 0205, (2018/03/25)
The present invention relates to a process for the preparation of an optically active carbonyl compound by asymmetric hydrogenation of a prochiral α,β-unsaturated carbonyl compound with hydrogen in the presence of at least one optically active transition metal catalyst that is soluble in the reaction mixture and which has rhodium as catalytically active transition metal and a chiral, bidentate bisphosphine ligand, wherein the reaction mixture during the hydrogenation of the prochiral α,β-unsaturated carbonyl compound additionally comprises at least one compound of the general formula (I): in which R1, R2: are identical or different and are C6- to C10-aryl which is unsubstituted or carries one or more, e.g. 1, 2, 3, 4 or 5, substituents which are selected from C1- to C6-alkyl, C3- to C6-cycloalkyl, C6- to C10-aryl, C1- to C6-alkoxy and amino;Z is a group CHR3R4 or aryl which is unsubstituted or carries one or more, e.g. 1, 2, 3, 4 or 5, substituents which are selected from C1- to C6-alkyl, C3- to C6-cycloalkyl, C6- to C10-aryl, C1- to C6-alkoxy and amino, wherein R3 and R4 are as defined in the claims and the description.
Process for Preparing Optically Active Diphosphanes
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Page/Page column 9, (2008/12/07)
The present invention relates to a process for preparing optically active bisphosphinylalkanes from the correspondingly substituted, racemic 1,2-diols. The optically active bisphosphinylalkanes which can be obtained in this way are suitable as ligands for preparing chiral transition metal catalysts.
Synthesis of chiraphos via asymmetric hydrogenation of 2,3- bis(diphenylphosphinoyl)-buta-1,3-diene
Beghetto, Valentina,Matteoli, Ugo,Scrivanti, Alberto
, p. 155 - 156 (2007/10/03)
(S,S)-2,3-Bis(diphenylphosphinoyl)butane, an immediate precursor of (S,S)-CHIRAPHOS, can be obtained with 70% de and 71% op via double asymmetric hydrogenation of 2,3-bis(diphenylphosphinoyl)buta-1,3-diene in the presence of Ru-(S)-BINAP catalysts.
Synthesis of the chiral diphosphine ligand 2,3-bis(diphenylphosphino)butane (CHIRAPHOS)
Matteoli, Ugo,Beghetto, Valentina,Schiavon, Cristina,Scrivanti, Alberto,Menchi, Gloria
, p. 1403 - 1409 (2007/10/03)
A new synthesis of CHIRAPHOS starting from readily available 2,3-bis(diphenylphosphinyl)- 1,3-butadiene has been devised. The key step of the synthesis is the hydrogenation of the diene to rac-2,3-bis(diphenylphosphinyl)butane. This reduction can be conve
